摘要
目的分析左氧氟沙星联合抗结核方案治疗菌阳矽肺肺结核的临床效果。方法选取菌阳矽肺肺结核患者80例,分成观察组(n=40)和对照组(n=40)。两组均采取抗结核方案进行治疗,观察组在此基础上同时联合应用左氧氟沙星。观察对比两组患者的临床治疗效果,治疗2个月和治疗6个月时的痰菌转阴率和不良反应发生率。结果对照组的临床治疗总有效率72.5%,观察组为92.5%,P <0.05。观察组患者治疗2个月和治疗6个月时的痰菌转阴率分别为85.0%和92.5%,对照组患者分别为57.5%和72.5%,P均<0.05。观察组和对照组患者的恶心呕吐、皮疹、粒细胞减少等不良反应发生分别为15.0%和17.5%,P> 0.05。结论左氧氟沙星联合抗结核方案治疗菌阳矽肺肺结核,可显著提高其痰菌转阴率和临床治疗效果,且不会增加不良反应。
Objective To analyze the clinical effect of levofloxacin combined with anti tuberculosis regimen in the treatment of pulmonary tuberculosis with bacteriological silicosis.Methods 80 cases of pulmonary tuberculosis with bacteriological silicosis were divided into observation group(n=40)and control group(n=40).Both groups were treated with anti-tuberculosis regimen,while the observation group was treated with levofloxacin.The clinical efficacy,sputum negative conversion rate and adverse reaction rate were observed and compared between the two groups after 2 months and 6 months of treatment.Results The total effective rate of the control group was 72.5%,while that of the observation group was 92.5%,P<0.05.In the observation group,the sputum negative conversion rate was 85.0%and 92.5%respectively at 2 months and 6 months,the patients in the control group were 57.5%and 72.5%,respectively,with P<0.05.The incidence of nausea,vomiting,rash and neutropenia was 15.0%and 17.5%respectively in the observation group and the control group,P>0.05.Conclusion Levofloxacin combined with anti-tuberculosis regimen can significantly improve the sputum negative rate and clinical treatment effect of bacillus-positive silicosis pulmonary tuberculosis without increasing adverse reactions.
作者
魏庆辉
WEI Qinghui(Department of Respiratory Medicine,Quangang District Hospital of Quanzhou City,Quanzhou Fujian 362801,China)
出处
《中国卫生标准管理》
2018年第21期66-68,共3页
China Health Standard Management
关键词
左氧氟沙星
抗结核方案
菌阳矽肺肺结核
治疗效果
痰菌转阴
不良反应
levofloxacin
antituberculosis regimen
pulmonary tuberculosis with bacteriological silicosis
therapeutic effect
sputum negative
adverse reactions
