摘要
目的探讨降钙素原、C-反应蛋白及血糖检测在手足口病患儿诊断中的应用价值。方法选取我院2016年3月～2017年10月收治的80例手足口病患儿作为研究组,按照不同病情分为研究1组(40例)与研究2组(40例)。研究1组为急性期手足口病患儿,研究2组为恢复期手足口病患儿,同期选取健康儿童40例作为对照组,对所有手足口病患儿、健康儿童使用全自动生化分析仪AU640及配套试剂检测C-反应蛋白及血糖,使用双抗夹心法和化学发光分析检测降钙素原。比较各组的降钙素原、C-反应蛋白及血糖差异结果。结果研究1组患儿的降钙素原、C-反应蛋白及血糖水平高于研究2组及对照组,差异有统计学意义(P<0.05)。研究2组的降钙素原、C-反应蛋白及血糖浓度均高于对照组,差异有统计学意义(P<0.05)。80例研究组患儿中,降钙素原检测阳性25例,C反应蛋白检测阳性32例,血糖检测阳性26例,联合检测阳性65例;40例对照组中,降钙素原检测阳性2例,C反应蛋白检测阳性4例,血糖检测阳性3例,联合检测6例。联合诊断的灵敏度、特异度高于单独诊断,差异有统计学意义(P<0.05)。结论对手足口病患儿予以降钙素原、C-反应蛋白及血糖检测,其阳性率较高,使用三项联合检测能够将手足口病患儿的诊断灵敏度有效提高,这为临床治疗提供了可靠的诊断依据。
Objective To investigate the application value of procalcitonin,C-reactive protein and blood glucose detection in the diagnosis of children with hand-foot-and-mouth diseases(HFMD).Methods A total of 80 HFMD children from March 2016 to October 2017 treated in our hospital were selected as the study group.They were divided into the study groupΙ(n=40)and the study groupⅡ(n=40)according to different disease conditions.Children in study groupΙwere at acute stages,while in study groupⅡ,participants were in the recovery period.At the same time,40 healthy children were selected as the control group.An automatic biochemical analyzer AU640 and matching reagents were used in HFMD children and healthy children for C-reactive protein and blood glucose detection.The procalcitonin was detected by double-antibody sandwich and chemiluminescence analysis.The differences in procalcitonin,C-reactive protein,and blood glucose were compared between the two groups.Results The levels of procalcitonin,C-reactive protein and blood glucose in the study groupΙwere higher than those in the study groupⅡand the control group,with significant difference(P<0.05).The levels of procalcitonin,C-reactive protein,and blood glucose were lower in the control group compared with those in the study groupsΙand the study groupⅡ,with significant difference(P<0.05).In the study group(n=80),positivity detection of procalcitonin was in 25 patients,of C-reactive protein was in 32 patients,of blood glucose was in 26 patients,and of combined detection in 65 potients.In the control group(n=40),positivity detection of procalcitonin was in 2 participants,of C-reactive protein was in 4 participants,of blood glucose was in 3 participants,and of combined detection in 6 participants.The sensitivity and specificity of combined diagnosis were higher than those of single diagnosis,with statistical significance(P<0.05).Conclusion The positivity rate of procalcitonin,C-reactive protein and blood glucose in children with HFMD is high.Joint application of these three tests can effectively improve the diagnostic sensitivity of children with HFMD and provide reliable diagnostic basis for clinical treatment.
作者
梁妤
LIANG Yu(Department of Pediatrics,People忆s Hospital of Yangchun City in Guangdong Province,Yangchun 529600,China)
出处
《中国当代医药》
2018年第30期119-121,共3页
China Modern Medicine
关键词
降钙素原
C-反应蛋白
血糖
手足口病
诊断价值
Procalcitonin
C-reactive protein
Blood glucose
Hand-foot-mouth disease
Diagnostic value
