摘要
目的探讨N-乙酰半胱氨酸联合小剂量阿奇霉素治疗慢性阻塞性肺疾病(COPD)稳定期气道黏液高分泌的效果。方法选择2016年1月～2017年10月在我院接受诊治的84例COPD稳定期患者作为观察对象,按照随机数字表法分为对照组和干预组,两组各42例。对照组接受常规治疗,干预组在对照组基础上加服N-乙酰半胱氨酸联合阿奇霉素治疗,持续治疗6个月后,比较两组患者的肺功能、活动耐力及血清炎性因子水平。结果治疗后,两组患者的第1s用力呼气容积(FEV_1)、用力肺活量(FVC)、FEV_1/FVC等肺功能指标比较,差异无统计学意义(P>0.05);治疗后干预组的6 min步行距离(6-MWD)长于对照组,差异有统计学意义(P<0.05);两组治疗后的血清炎性因子中性粒细胞弹性蛋白酶(NE)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)水平均低于治疗前,差异有统计学意义(P<0.05);治疗后干预组的血清炎性因子NE、IL-8、IL-10水平低于对照组,差异有统计学意义(P<0.05)。结论 N-乙酰半胱氨酸联合小剂量阿奇霉素治疗COPD稳定期效果显著,能提高活动耐力,减轻炎症反应,减少气道黏液的分泌,延缓患者肺功能减退,值得临床推广。
Objective To investigate the effect of N-acetylcysteine combined with low-dose Azithromycin on airway mucus hypersecretion in stable phase of chronic obstructive pulmonary disease(COPD).Methods Eighty-four patients with stable COPD treated in our hospital from January 2016 to October 2017 were selected as observation objects,they were divided into control group and intervention group according to random number table method,with 42 cases in each group.The control group received routine treatment,and the intervention group received N-acetylcysteine and Azithromycin on the basis of the control group,after 6 months of continuous treatment,the lung function,activity endurance and serum inflammatory factors were compared between the two groups.Results There was no significant difference between the two groups in the first second forced expiratory volume(FEV1),forced vital capacity(FVC)and FEV1/FVC(P>0.05);After treatment,the 6-minute walking distance(6-MWD)of intervention group was longer than that of control group,the differences were statistically significant(P<0.05).The levels of serum inflammatory factors,neutrophil elastase(NE),interleukin-8(IL-8)and interleukin-10(IL-10)in the two groups after treatment were lower than those before treatment,the differences were statistically significant(P<0.05).After treatment,the levels of serum inflammatory factors NE,IL-8 and IL-10 in intervention group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion N-acetylcysteine combined with low-dose Azithromycin in the treatment of stable COPD effect is significant,can improve activity endurance,reduce inflammation,reduce airway mucus secretion,delay the decline of pulmonary function,worthy of clinical promotion.
作者
李发根
陈贤翔
LI Fa-gen;CHEN Xian-xiang(Department of respiration,Nanping 92th Hospital of Fujian Province,Nanping 353000,China;Department of Pathology,Nanping 92th Hospital of Fujian Province,Nanping 353000,China)
出处
《中国当代医药》
2018年第30期104-106,共3页
China Modern Medicine
作者简介
李发根(1980-),男,本科,主治医师,研究方向:呼吸内科。
