摘要
胸腹部肿瘤放疗时,位于纵隔的心脏不可避免受到照射而引起的心脏损伤,统称为放射性心脏损伤(radiation-induced heart damage,RIHD),该病已被认为与传统的放射性肺纤维化损伤同等重要,是严重的放疗副反应。近年来,学者们对RIHD方面的研究逐渐升温。目前该领域临床观察较多,基础研究不足,病因机制尚不明确,还处于以"认知"为主的阶段,缺乏有效干预措施。因此利用动物实验进行RIHD基础研究,深入探索射线引起心脏损伤的病理分子机制,积极尝试可能的干预手段具有迫切的现实意义。本文对实验研究中动物造模、指标检测、病理机制、药物干预及其药理作用等方面的RIHD基础研究结果进行综述,以期为今后RIHD研究提供一定参考。
Radiation-induced heart damage(RIHD)is unavoidable in the mediastinal heart during radiotherapy for chest and abdominal tumors.This condition has been considered to be important in conventional radiation-induced pulmonary fibrosis.It is a severe side effect of radiotherapy.In recent years,research on RIHD has gradually increased in intensity.At present,many clinical observations are being undertaken in this field,but the basic research is insufficient,the etiological mechanism is not clear,and there is a lack of effective intervention.Therefore,there is an urgent need to carry out animal experiments as basic research on RIHD,to explore the pathomolecular mechanisms of cardiac injury induced by radiation and to actively develop potential intervention measures.This paper reviews the result of basic research on RIHD in terms of animal modeling,index detection,pathological mechanism,drug intervention,and pharmacological action in order to provide a reference for future RIHD research.
作者
顾静
吴红彦
张雪燕
刘润
李海龙
郭超
GU Jing;WU Hongyan;ZHANG Xueyan;LIU run;LI Hailong;GUO Chao(Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2018年第5期667-671,共5页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金(81660742)
甘肃省中医药管理局科研课题(GZK-2015-43)
中国博士后科学基金面上资助(2017M620477)~~
关键词
放射性心脏损伤
基础研究
动物实验
radiation-induced heart damage
basic research
animal experiment
