摘要
采用回顾性分析方法,统计我院467例急性心肌梗死(AMI)住院患者的临床特征和β受体阻滞剂的使用状况,并运用二分类Logistic回归分析其影响因素。结果显示,AMI患者β受体阻滞剂的使用率仅为64.0%,Logistic回归分析表明,合并2型糖尿病(OR=1.761)、心力衰竭(OR=1.654)、入院时收缩压≥140 mmHg(OR=1.826)、入院时心率>70次/min(OR=1.797)的患者更倾向于使用β受体阻滞剂(P<0.05);入院时收缩压<100 mmHg(OR=0.094)和左室射血分数未测量(OR=0.481)的患者更倾向于不使用β受体阻滞剂(P<0.05);左室射血分数≤40%(OR=1.281)的患者倾向于使用β受体阻滞剂,但差异无统计学意义(P>0.05)。在AMI患者中,β受体阻滞剂的临床应用情况与"指南"间存在一定的差距,应加强认识并重视药物治疗。
Clinical data and application of beta receptor blockers of 467 hospitalized patients with acute myocardial infarction(AMI)were retrospectively analyzed,and the related factors influencing the utilization of beta receptor blockers were identified by binary logistic regression analysis.The results showed that the application rate of beta receptor blockers was only 64.0%.The multi-factor analysis showed that the patients with diabetes(OR=1.761),heart failure(OR=1.654),systolic blood pressure(SBP)≥140 mmHg(OR=1.826)or heart rate>70 beats/min(OR=1.797)at admission were more likely to accept beta receptor blocker therapy(P<0.05);the patients with SBP<100 mmHg(OR=0.094)or left ventricular ejection fraction(LVEF)unmeasured(OR=0.481)were less likely to receive beta receptor blocker therapy(P<0.05).Patients with LVEF≤40%(OR=1.281)were inclined to receive beta receptor blocker therapy but without statistical significance(P>0.05).There was an obvious gap between the present situation and the guideline for beta receptor blocker therapy in most of these patients with AMI,which should be improved.
作者
陈瑾瑾
刘培延
张倩
CHEN Jinjin;LIU Peiyan;ZHANG Qian(Department of Pharmacy,Nanjing First Hospital,Nanjing 210006,China)
出处
《药学与临床研究》
2018年第5期371-374,共4页
Pharmaceutical and Clinical Research
作者简介
陈瑾瑾,女,药师E-mail:pxchenjin@163.com;通讯作者张倩,女,药师E-mail:zhangq0619@163.com。
