摘要
目的探讨^(18)F-FDG脑代谢联合^(11)C-CFT脑多巴胺转运体(DAT)及^(11)C-RAC脑多巴胺D2受体(D_2R)正电子发射断层显像(PET)应用于帕金森病(PD)病情严重程度、脑损伤部位评价以及诊断的临床价值。方法将22例临床诊断为PD的患者和23例对照组分别进行^(18)F-FDG、^(11)C-CFT及^(11)C-RAC PET显像,分析3种示踪剂显像特点;进一步根据^(11)C-CFT PET显像特点把PD组分为轻、中、重度组,分析不同情况相对应的PD组^(18)F-FDG及^(11)C-RAC PET显像,进行PD脑损伤部位的评价及病情分析。结果 ^(18)F-FDG PET示双侧基底节区放射性分布低于同侧对照组,并壳核代谢高于尾状核,而^(11)C-CFT表现为双侧尾状核、双侧壳核前、中、后部放射性分布低于同侧对照组;^(11)C-RAC PET示双侧壳核中、后部放射性分布高于同侧对照组;根据^(11)C-CFT PET显像特点分为轻、中度的PD组在^(18)F-FDG PET示双侧尾状核、单侧壳核前部、双侧壳核中部、单侧壳核后部放射性分布低于对照组,重度PD组仅双侧尾状核放射性分布低于对照组;根据^(11)C-CFT PET显像特点分为轻、中、重度的PD组在^(11)CRAC PET示双侧壳核中、后部放射性分布高于对照组。结论 ^(18)F-FDG、^(11)C-CFT、^(11)C-RAC PET显像联合检查有助于PD的病情分析、脑损伤部位评价以及诊断。
Objective To explore the application value of 18 F-FDG cerebral metabolic,11 C-CFT dopamine transportor and 11 C-RAC dopamine D-2 recepter PET image mode in the evaluation of brain injury site,severity assessment and diagnosis of Parkinsons disease(PD).Methods Twenty-two PD patients and Twenty-three healthy controls were performed 18 F-FDG,11 C-CFT and 11C-RAC positron emission tomography,and to analyze the imaging characteristics of three tracer;furthermore based on the characteristics of 11 C-CFT PET image,PD patients were divided into mild,moderate and severe installment groups,and to analyze features of the 18 F-FDG and 11 C-RAC PET image to evaluate their brain injury sites.Results The uptake value of 18 F-FDG mainly in bilateral basal gengila decreased symmetrically,the uptake value of putamen were higher than caudate nucleus,and the uptake value of 11 C-CFT distribute in bilateral caudate nucleus,bilateral anterior-putamen,medio-putamen and posterior-putamen were decreased;the uptake value of 11 C-RAC were increased in the bilateral medio-putamen and posterior-putamen on the same side;the corresponding uptake value of 18 F-FDG were decreased in the bilateral caudate nucleus,one side anterior-putamen,bilateral medio-putamen and one side posterior-putamen of the mild and moderate PD groups,and only a bilateral caudate nucleus decreased in the severe PD group,while the corresponding 11 C-RAC PET express increased in the bilateral medio-putamen and posterior-putamen on the same side.Conclu-sion 18 F-FDG combined with 11 C-CFT and 11 C-RAC PET image has application value in the evaluation of brain injury site,severity assessment and diagnosis of Parkinsons disease.
作者
那孜木古丽.木塔尔别克
张奇洲
秦永德
李毓斌
李肖红
阿米娜.依不拉音
Nazimuguli Mutaerbieke;ZHANG Qizhou;QIN Yongde;LI Yubin;LI Xiaohong;AminaYibulayin(Department of Nuclear Medicine,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《新疆医科大学学报》
CAS
2018年第10期1217-1222,共6页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区科技计划项目(201417101)
作者简介
那孜木古丽·木塔尔别克(1988-),女,在读硕士,研究方向:神经核医学;通信作者:秦永德,男,主任医师,教授,博士生导师,研究方向:神经与肿瘤核医学,E-mail:qyd199013@163.com。
