摘要
为了提高壳聚糖的水溶性及其止血方面的性能,将壳聚糖(CS)纳米化,并引入具有抗菌作用的Ag^+离子和凝血辅助作用的Ca^(2+)离子,制备出纳米壳聚糖金属离子复合止血材料。首先,采用离子交换法制备纳米壳聚糖(nmCS),再分别加入AgNO_3和饱和CaCl2溶液,制得nmCS-Ag、nmCS-Ca、nmCS-Ag-Ca复合材料。然后,采用FTIR、XRD、SEM等手段对复合材料的结构进行表征。最后,对复合物的凝血、止血性能进行了测试。实验结果表明:改性后的壳聚糖IR图谱在1647cm-1和1560cm-1处出现了纳米壳聚糖钠盐的特征吸收峰;复合了金属离子的纳米壳聚糖在XRD图谱中表现出了Ag^+、Ca^(2+)的晶型特征;扫描电镜显示nmCS-Ag中Ag^+有部分析出而nmCS-Ca的复合效果较好;nmCS-Ag-Ca的凝血、止血效果要优于nmCS-Ag和nmCS-Ca,同时nmCS-Ag和nmCS-Ca的凝血、止血效果要优于nmCS。测试结果表明,成功制备了纳米壳聚糖金属离子复合止血材料。
In order to improve the water soluble and the hemostatic performance of chitosan(CS),chitosan is nano-sized and an antibacterial Ag+and coagulation-assisted Ca 2+are introduced to prepare a nano-chitosan metal ion composite hemostatic material.Firstly,nano-chitosan(nmCS)is prepared by ion exchange method,and AgNO 3 and saturated CaCl 2 solution are added respectively to obtain nmCS-Ag,nmCS-Ca and nmCS-Ag-Ca composites.Then,the structure of the composite is characterized by means of FTIR,XRD and SEM.Finally,the coagulation and hemostatic properties of the complex are tested.The results show that the characteristic absorption peak of nano-chitosan sodium salt appeared at the modified chitosan IR spectrum at 1 647 cm-1 and 1 560 cm-1.The nano-chitosan composited with metal ions show the crystal characteristics of Ag+and Ca 2+in the XRD pattern.The SEM shows that partial Ag+precipitates in nmCS-Ag,and the composite effect of nmCS-Ca is better.The coagulation and hemostasis of nmCS-Ag-Ca is better than that of nmCS-Ag and nmCS-Ca,while the coagulation and hemostasis of nmCS-Ag and nmCS-Ca are better than that of nmCS.The test results show that the nano-chitosan metal ion composite hemostatic material has been successfully prepared.
作者
董丽丹
魏长平
李中田
汪凤明
DONG Li-dan;WEI Chang-ping;LI Zhong-tian;WANG Feng-ming(School of Materials Science and Engineering,Changchun University of Science and Tech.,Changchun 130022,China;School of drug and food,Changchun Medical College,Changchun 130031,China;China Water Northeastern Investigation,Design and Research Co.,Ltd,Changchun 130061,China)
出处
《中国光学》
EI
CAS
CSCD
北大核心
2018年第5期773-778,共6页
Chinese Optics
基金
中国科协"海外智力为国服务行动计划"项目(No.07064)
吉林省教育厅"十二五"科学技术研究项目(吉科教合字【2013】第36号)资助~~
关键词
壳聚糖
复合材料
纳米
性能
nano-chitosan
composite materials
characterization
performance
作者简介
董丽丹(1980—),女,吉林长春人,硕士,讲师,2007年于长春理工大学获得硕士学位,现为长春医学高等专科学校讲师、长春理工大学在读博士研究生,主要从事医用壳聚糖材料方面的研究。E-mail:573972433@qq.com;魏长平(1960—),女,吉林长春人,教授,博士生导师,1999年于吉林大学获得博士学位,主要从事医用基础功能材料的研究。E-mail:changpingwei@hotmail.com
