摘要
目的: 探讨拉莫三嗪联合丙戊酸钠治疗小儿癫痫的疗效。方法: 根据随机数字表法将90例小儿癫痫患儿分成两组。单一用药治疗组给予丙戊酸钠治疗,联合用药治疗组则给予丙戊酸钠联合拉莫三嗪治疗。比较两组小儿癫痫治疗转归效果;癫痫发作控制的平均时间;治疗前后患儿血清学相关生化指标;用药安全性。结果: 联合用药治疗组小儿癫痫治疗转归效果、癫痫发作控制的平均时间优于单一用药治疗组(P<0.05)。治疗前两组血清超敏C反应蛋白、肿瘤坏死因子-α、血细胞比容、同型半胱氨酸、红细胞沉降率无明显差异(P>0.05);治疗后联合用药治疗组的上述血清学生化指标均优于单一用药治疗组(P<0.05)。联合用药治疗组用药安全性与单一用药治疗组无明显差异(P>0.05)。结论: 丙戊酸钠联合拉莫三嗪治疗小儿癫痫的疗效确切,可有效改善血清学相关生化指标,缩短癫痫发作控制的平均时间,用药安全。
Objective:To investigate the efficacy of lamotrigine combined with sodium valproate in the treatment of children with epilepsy.Methods:Ninety children with epilepsy were divided into a single-drug group and a combination group by a random number table method.The single-drug group was treated with sodium valproate while the combination group was treated with sodium valproate combined with lamotrigine.The treatment outcome,the mean time for seizure control,the serologically relevant biochemical indicators and medication safety were compared between the two groups.Results:The outcome of treatment and the mean time for seizure control were much better in the combination group than in the single-drug group(P<0.05).There were no significant differences between the two groups in the serologically relevant biochemical indicators before treatment and medication safety(P>0.05),however,these indicators were also much better in the combination group than in the single-drug group after treatment(P<0.05).Conclusion:The combination therapy possesses exact efficacy in the treatment of epilepsy of children,can effectively improve the serologically relevant biochemical indicators and shorten the mean time for seizure control with good medication safety.
作者
钟涛
ZHONG Tao(Department of Pediatrics,Ganzhou People’s Hospital,Jiangxi Ganzhou 341000,China)
出处
《上海医药》
CAS
2018年第17期25-26,32,共3页
Shanghai Medical & Pharmaceutical Journal
关键词
拉莫三嗪
丙戊酸钠
小儿癫痫
lamotrigine
sodium valproate
childhood epilepsy
