摘要
目的:探讨重组人粒细胞刺激因子注射液(G-CSF)含漱治疗氟尿嘧啶化疗所致口腔溃疡的临床疗效。方法:选取2014年5月至2017年5月化疗后并发口腔溃疡的64例患者,随机分为观察组和对照组,每组32例。观察组使用粒细胞集落刺激因子含漱治疗;对照组应用氯己定含漱治疗。对比两组患者治疗的有效率和治愈所需的时间。结果:观察组的有效率及平均愈合时间分别为96.88%和(3.7±1.3)d,优于对照组的78.13%和(6.0±0.9)d,差异具有统计学意义(P<0.05)。结论:重组人粒细胞刺激因子注射液含漱治疗化疗后口腔溃疡可提高疗效并缩短溃疡愈合时间。
Objective:To discuss the efficacy of recombinant human granulocyte-colony-stimulating factor(G-CSF)in the treatment of oral ulcer caused by chemotherapy with fluorouracil.Method:64 patients of oral ulcer caused by chemotherapy from May,2014 to May,2017 were randomly divided into two groups.32 patients in the treatment group were treated with recombinant human granulocyte-colony-stimulating factor,and 32 patients in the control group with the treatment of chlorhexidine.The effective rate and cure time of the two groups were compared.Results:The effective rate and average cure time of the treatment group were 96.88%and 3.67±1.33 days respectively,which were better than 78.13%and 6.01±0.87 days in the control group(P<0.05).Conclusion:Recombinant human granulocyte-colony-stimulating factor can improve the efficacy of oral ulcer caused by chemotherapy and shorten the cure time.
作者
郜娜娜
侯晶晶
马馨
GAO Nana;HOU Jingjing;MA Xin(Department of Medical Oncology,The First Affiliated Hospital of Henan Polytechnic University,Jiaozuo 454000,China)
出处
《包头医学院学报》
CAS
2018年第7期40-42,共3页
Journal of Baotou Medical College
关键词
重组人粒细胞刺激因子
氟尿嘧啶
化疗
口腔溃疡
Recombinant human granulocyte-colony-stimulating factor
Fluorouracil
Chemotherapy
Oral ulcer
