摘要
目的基于流固耦合(FSI)分析不同级别椎基底动脉延长扩张症(VBD)病人的流体力学分布特点及与脑梗死的相关性。方法收集2015年2月—2017年2月在天津市第四中心医院诊断为后循环缺血的VBD病人34例,均行头颈CT血管成像(CTA)及MRI检查,其中男20例,女14例,年龄25~80岁,平均(62.1±12.3)岁。按照Smoker分级标准,将VBD分为0、1、2、3级,并将病人头颈CTA的原始数据建立有限元模型,之后调入力学仿真软件ANSYS Workbench中进行分析,选择壁面剪切力(WSS)、壁面压力(WP)、血流速度为输出变量。采用单因素方差分析比较不同级别VBD组间血流参数差异。采用Pearson相关和回归分析评价血流参数与后循环脑梗死的相关性。结果随着VBD级别的升高,基底动脉小弯侧WSS、小弯侧血流速度、大弯侧WP的数值趋于降低(均P<0.05);脑梗死的发生率也随之增高(P=0.02)。小弯侧WSS、小弯侧血流速度、大弯侧WP与脑梗死发生分别呈负相关(r分别为-0.70、-0.58、-0.78,均P<0.05);回归R^2分别为0.50、0.63、0.62。结论基于FSI分析可以观察不同级别VBD的流体力学特点,并且提供VBD发展的理论依据。随着VBD级别升高,流体力学参数与后循环脑梗死呈负相关。
Objective Using Fluid Structure Interaction(FSI)to analyze the relationship between the characteristics of fluid mechanics distribution and cerebral infarction in patients with different levels of vertebrobasilar dolichoectasia(VBD).Methods All of 34 patients(62.1±12.3 years old,range 25 to 80 years,20 males and 14 females)with posterior circulation ischemia were selected in Tianjin Fourth Central Hospital,during Feb.2015-Feb.2017.Each patient underwent CTA and MRI,and VBD was confirmed.According to the Smoker grading standard,the VBD were divided into four levels-level 0,1,2,and 3.Basing on their original data of head and neck CTA,a finite-element model was built,then the model was fed into ANSYS Workbench for analysis.The wall shear stress(WSS),wall pressure(WP)and blood flow velocity were calculated.One-way ANOVA was employed to analyze the differences in hemodynamic parameters between different levels of VBD.Pearson correlation and regression analysis were conducted to evaluate the correlation between blood flow parameters and posterior circulation cerebral infarction.Results As the level of VBD increased,the WSS and blood flow velocity were at small curved side,and the WP at large curved side were decreased(all P<0.05);the incidence of cerebral infarction was increased(P=0.02).The WSS and blood flow velocity at small curved side,and the WP at large curved side negatively correlated with the incidence of cerebral infarction.The correlation coefficients were-0.70,-0.58,-0.78,respectively(all P<0.05),and the R2 were 0.50,0.63,0.62,respectively.Conclusion FSI analysis may characterize the hydromechanics of different levels of VBD,and can provide theoretic support for VBD research.As the level of VBD increases,hydromechanical parameters negatively correlate with incidence of posterior circulation cerebral infarction.
作者
李建伟
宋金玉
纪盛章
郑珺
LI Jianwei;SONG Jinyu;JI Shengzhang;ZHENG Jun(Tianjin Fourth Central Hospital,Tianjin 300140,China)
出处
《国际医学放射学杂志》
北大核心
2018年第4期388-391,共4页
International Journal of Medical Radiology
关键词
流固耦合
椎基底动脉延长扩张症
壁面剪切力
壁面压力
血流速度
脑梗死
Fluid Structure Interaction
Vertebrobasilar dolichoectasia
Wall shear stress
Wall pressure
Blood flow velocity
Cerebral infarction
作者简介
通信作者:纪盛章,E-mail:jsz0549@163.com。
