摘要
目的:探讨特布他林联合清肺化痰汤治疗老年慢性阻塞性肺疾病(COPD)的临床疗效情况。方法:选取老年COPD患者86例,随机分为观察组和对照组各43例,对照组给予特布他林治疗,观察组在此基础上给予清肺化痰汤治疗。比较两组患者疗效情况,及治疗后两组患者肺功能及免疫功能情况,检测治疗后两组患者血清PCT、Endotoxin及GLU表达水平情况。观察治疗后两组患者循环炎性因子表达水平(IL-13、C-反应蛋、TNF-α)和呼吸衰竭指数水平情况。结果:观察组患者治疗有效率(97.67%)明显高于对照组(72.09%),差异具有统计学意义(P<0.05)。观察组的肺功能各项指标明显优于对照组,差异具有统计学意义(P<0.05)。观察组CD3+、CD4+、CD4+/CD8+水平高于对照组,CD8+水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组PCT、Endotoxin及GLU水平明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患者C-反应蛋白、TNF-α和IL-13水平明显低于对照组,RFI明显高于对照组,差异具有统计学意义(P<0.05)。结论:对COPD急性加重期痰热郁肺证型患者,采用清金化痰汤合麻杏石甘汤治疗治疗,可明显缓解临床症状,改善炎症反应症状,改善其肺功能并对调节免疫功能有一定作用。
Objective:To investigate the clinical efficacy of terbutaline combined with Qingfei Huatan decoction in the treatment of chronic obstructive pulmonary disease(COPD)in the elderly.Methods:86 elderly COPD patients in our hospital were randomly divided into the observation group(43 cases)and the control group(43 cases).The control group was given terbutaline treatment,and the observation group was given Qingfei Huatan decoction on the basis of this treatment.The curative effect of two groups was compared.The lung function and immune function of two groups after treatment were compared.The levels of serum PCT,Endotoxin and GLU were detected after treatment in two groups.The levels of circulating inflammatory factors(IL-13,C-reaction,TNF-alpha)and respiratory failure index in the two groups were observed after treatment.Results:The effective rate of treatment in the observation group(97.67%)was significantly higher than that of the control group(72.09%),and the difference was statistically significant(P<0.05).The indexes of lung function of the observation group were obviously superior to those of the control group,and the difference was statistically significant(P<0.05).The level of CD 3+,CD 4+and CD 4+/CD 8+in the observation group was higher than that of the control group,and the level of CD 8+was lower than that of the control group.The difference was statistically significant(P<0.05).After treatment,the levels of PCT,Endotoxin and GLU in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of C-reactive protein,TNF-alpha and IL-13 in the observation group were significantly lower than those in the control group,RFI was significantly higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The acute exacerbation of COPD of phlegm heat obstructing lung syndrome patients,using Qingfei Huatan decoction and Maxing Shigan decoction treatment,can significantly relieve the clinical symptoms,improve inflammation symptoms,improve the pulmonary function and has certain effect on regulating the immune function.
作者
张芳
Zhang Fang(Department of Pulmonary Disease,Anyang Hospital of Traditional Chinese Medicine(Anyang 455000))
出处
《陕西中医》
2018年第5期580-583,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
河南省医学科技攻关计划项目(201304099)
关键词
肺疾病
慢性阻塞性/中西医结合疗法
@清肺化痰汤
@特布他林
Pulmonary disease,chronic obstructive/integrated Chinese traditional and western medicine therapy
@Qingfei Huatan decoction
@Terbutaline
