摘要
目的探讨肺梭形细胞癌的临床病理特征及预后。方法收集2012年1月至2014年12月郑州大学第一附属医院确诊的15例肺梭形细胞癌患者的临床资料,应用Kaplan-Meier法计算生存率并绘制生存曲线。结果 6058例肺癌患者中15例确诊为肺梭形细胞癌,其中男性12例,女性3例,中位年龄58岁,9例有大量吸烟史。CT显示肿瘤平均直径(53.6±20.3)mm,其中2例侵犯相邻结构,12例为外周型。7例患者行PET-CT,肿块平均标准摄取值为12.8±4.3,高于其他同分期的非小细胞型肺癌(NSCLC)(P=0.003)。中位生存期为12.1个月,接受外科治疗的11例患者中复发和转移较常见,手术治疗患者较非手术者生存时间更长(P=0.01),术后化疗患者较未行化疗手术患者在生存时间未能明显获益(P=0.03)。结论肺梭形细胞癌极为罕见,侵袭性强,易复发、转移,对化疗反应差,目前早期手术为主要治疗办法。
Objective To analyze the clinical characteristics and prognosis of spindle cell carcinoma of the lung(SpCC).Methods A total of 15 patients were hospitalized at our hospital between 2012 and 2014 for treatment of SpCC.We retrospectively analyzed their clinical characteristics and prognosis.Results Fifteen of 6058 patients with primary lung cancer were diagnosed with SpCC.Of them,twelve were male and three were female,with a median age of 58.0 years.Nine were current-or ex-smokers with substantial smoking histories.Computed tomography(CT)findings revealed that the tumors were quite large(mean diameter,53.6±20.3 mm),with three cases having invasion of adjacent structures and 12 tumors located peripherally.Positron emission tomography-CT(PET-CT)was performed in seven patients,and the standardized uptake value(SUV)tended to be high(12.8±4.3),which was significantly higher than other NSCLC cases at the same stage(P=0.003).The median survival was 12.1 months.In 11 patients who underwent surgical treatment,recurrence and metastases frequently occurred.Patients who had undergone surgical resection survived longer than those who did not(P=0.01).Postoperative chemotherapy did not significantly prolong the survival time(P=0.03).Conclusions SpCC of the lung is extremely rare and has strong malignant potential with frequent recurrence and distant metastases.Response to chemotherapy is generally poor.Surgical treatment at early stage might result in better prognosis.
作者
邵志鹏
赵松
张仁锋
魏创业
龙勇
Shao Zhipeng;Zhao Song;Zhang Renfeng;Wei Chuangye;Long Yong(Department of Thoracic Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou Key Laboratory of Thoracic Oncology,Zhengzhou 450052,China)
出处
《中华临床医师杂志（电子版）》
CAS
2018年第2期90-94,共5页
Chinese Journal of Clinicians(Electronic Edition)
关键词
肺梭形细胞癌
临床特征
治疗
预后
Spindle cell carcinoma of the lung
Clinical characteristics
Therapy
Prognosis
作者简介
通信作者:赵松,Email:songzhao2017@163.com
