摘要
肿瘤相关成纤维细胞(CAFs)作为肿瘤微环境中的主要细胞类型,其生物学特性具有来源、表型和功能异质性,通过产生和分泌各种趋化因子和促进上皮间充质转化,从而促肿瘤生成、增殖、侵袭和转移。CAFs可介导肿瘤干细胞支持肿瘤产生及增殖,促使肿瘤细胞放疗抵抗。CAFs还可通过旁分泌外泌体,增强肿瘤的生长和能诱导放疗抵抗。大分割放疗应用于CAFs,可诱导CAFs表达衰老表型发生变化,促肿瘤能力下降,为临床肿瘤的放疗带来新契机。
Tumor-associated fibroblasts(TAFs)as the main cell types in the tumor microenvironment,with the biological characteristics of origin,phenotypic and functional heterogeneity,producing and secreting a variety of chemokines,which facilitate the epithelial-mesenchymal transition,thus promote the tumor generation,proliferation,invasion and metastasis.CAFs play a key role in mediating CSCs to support tumor genesis and proliferation and resist radiotherapy.Furthermore,CAFs can also secrete exosome,enhancing tumor growth and inducing radiotherapy resistance.The application of high-dose radiotherapy to CAFs can induce the expression of the aging phenotype in CAFs and decrease the tumor promoting ability,bringing new opportunities for the clinical radiotherapy.
作者
毛羽驰
莫文倩
何环宇
张旭林
李懿
MAO Yuchi;MO Wenqian;HE Huanyu;ZHANG Xulin;LI Yi(Clinical College of Kunming General Hospital of Chengdu Military Command of Kunming Medical University,Kunming 650032,China;Department of Oncology,Kunming General Hospital of Chengdu Military Command,Kunming 650032,China)
出处
《医学综述》
2018年第5期895-900,共6页
Medical Recapitulate
基金
国家自然科学基金(81572904)
作者简介
通信作者:李懿,E-mail:liyi3443@hotmail.com
