摘要
目的探讨地塞米松联合丙种球蛋白治疗小儿过敏性紫癜性肾炎的临床效果。方法选取2014年3月~2017年3月我院收治的50例过敏性紫癜性肾炎患儿作为研究对象,依据治疗方式的不同将其分为对照组(n=20)和观察组(n=30)。对照组患儿者采用地塞米松治疗,观察组患儿采用地塞米松联合丙种球蛋白治疗。观察两组患儿治疗前后的纤维蛋白原含量(FIB)、凝血酶原时间(PT)和部分凝血活酶时间(APTT)、24 h尿蛋白、尿红细胞水平情况,观察两组患儿临床疗效情况。结果两组患儿治疗前后的PT比较,差异均无统计学意义(P>0.05)。治疗前,两组患儿的FIB、APTT、24 h尿蛋白、尿红细胞水平比较,差异无统计学意义(P>0.05)。治疗后,对照组和观察组患儿的FIB分别是(2.9±0.3)g/L与(2.0±0.2)g/L、24 h尿蛋白分别是(0.14±0.03)g与(0.10±0.02)g、尿红细胞水平分别是(1.9±0.4)×107个与(1.1±0.5)×107个,均低于对照组和观察组患儿治疗前的FIB[(3.6±0.2)g/L,(3.7±0.3)g/L]、24 h尿蛋白[(0.18±0.05)g,(0.19±0.06)g]、尿红细胞水平[(4.8±0.4)×107个,(4.7±0.5)×107个],对照组和观察组患儿的APTT分别是(26.0±1.8)s与(28.9±2.1)s,均高于对照组和观察组患儿治疗前的APTT[(24.0±2.2)s,(23.9±2.0)s],且观察组患儿治疗后FIB、24 h尿蛋白、尿红细胞水平低于对照组,APTT高于对照组,差异均有统计学意义(P<0.05)。观察组患儿的临床治疗总有效率(96.7%)高于对照组(80.0%),差异有统计学意义(P<0.05)。结论地塞米松联合丙种球蛋白治疗过敏性紫癜性肾炎患儿,凝血功能和24 h尿蛋白、尿红细胞水平改善明显,效果良好,值得临床推广应用。
Objective To investigate the clinical effect of Dexamethasone combined with Gamma Globulin in the treatment of children with Henoch-Schonlein purpura nephritis(HSPN).Methods The clinical data of 50 children with HSPN who were treated in our hospital from March 2014 to March 2017 were analyzed,all the patients were divided into the control group(n=20)and observation group(n=30)according to different treatment methods.The control group was treated with Dexamethasone,while the observation group was treated with Dexamethasone combined with Gamma Globulin.The pre-operative and post-operative fibrinogen(FIB),prothrombin time(PT),activated partial thromboplastin time(APTT),24 h urine protein and urine red blood cell levels of two groups were observed,and the clinical efficacy of the two groups was observed.Results The pre-operative and post-operative PT of two groups had no statistically significant difference(P>0.05).The pre-operative FIB,APTT,24 h urine protein and urine red blood cell levels of two groups had no statistically significant difference(P>0.05).The post-operative FIB of control group and observation group were(2.9±0.3)g/L and(2.0±0.2)g/L respectively,the 24 h urine protein were(0.14±0.03)g and(0.10±0.02)g respectively,the urine red blood cell levels were(1.9±0.4)×107 and(1.1±0.5)×107 respectively,which were both lower than pre-operative levels of FIB([3.6±0.2]g/L,[3.7±0.3]g/L),the 24 h urine protein([0.18±0.05]g,[0.19±0.06]g),the urine red blood cell([4.8±0.4]×107,[4.7±0.5]×107)respectively,the post-operative APTT of control group and observation group were(26.0±1.8)s and(28.9±2.1)s respectively,which were higher than pre-operative levels of APTT([24.0±2.2]s,[23.9±2.0]s)respectively,while the post-operative FIB,24 h urine protein and urine red blood cell levels of the observation group were lower than those of the control group,and the post-operative APTT of the observation group was higher than that of the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was 96.7%,which was higher than that of the control group(80.0%),with statistically significant difference(P<0.05).Conclusion Application of combination of dexamethasone and gamma globulin in the treatment of children with Henoch-Schonlein purpura nephritis has good effect and significant improvement in coagulation function,24h urinary protein and urine red blood cell levels,which is worthy of clinical application.
作者
谢金金
肖贞
袁红玲
XIE Jin-jin;XIAO Zhen;YUAN Hong-ling(Department of Pediatrics,Xiaolan People′s Hospital of Zhongshan City,Guangdong Province,Zhongshan 528415,China;Department of Rehabilitation,Xiaolan People′s Hospital of Zhongshan City,Guangdong Province,Zhongshan 528415,China)
出处
《中国当代医药》
2018年第10期140-143,共4页
China Modern Medicine
基金
广东省中山市医学科研项目(2015A020054)
关键词
地塞米松
丙种球蛋白
小儿
过敏性紫癜性肾炎
凝血功能
24h尿蛋白
尿红细胞
Dexamethasone
Gamma Globulin
Children
Henoch-Schonlein purpura nephritis
Coagulation function
24 h urine protein
Urine red blood cell
