摘要
目的探析心肌酶谱、高敏肌钙蛋白T诊断小儿手足口病并发心肌损伤的临床应用价值。方法选择2016年4月至2017年1月湖北医药学院附属太和医院收治的手足口病患儿100例,根据心电图检查结果分为心电图正常组(n=40)和心电图异常组(n=60),同期选择体检健康者50例为对照组,比较三组的心肌酶同工酶(CK-MB)、肌酸激酶(CK)、α-羟丁酸脱氢酶(α-HBDH)、乳酸脱氢酶(LDH)、天冬氨酸氨基转移酶(AST)、高敏肌钙蛋白T(hs-cTnT),并比较手足口病异常心电图组患儿急性期与恢复期的hs-cTnT、CK等生化指标。结果手足口病患儿心电图异常组的CK-MB、CK、α-HBDH、LDH、AST、hs-cTnT明显高于手足口病患儿心电图正常组和对照组,差异有统计学意义(P<0.05)。手足口病患儿心电图异常组急性期CK-MB、CK、α-HBDH、LDH、AST、hs-cTnT水平明显高于手足口病患儿心电图异常组恢复期,差异均有统计学意义(P<0.05)。结论心肌损伤为手足口病患儿的严重并发症,监测患儿的hs-cTnT、心肌酶谱等生化指标对手足口病患儿心肌损伤的诊治具有重要的临床价值。
Objective To explore the clinical application value of muscle enzymes and high sensitivity cardiac troponin T(hs-cTnT)in children with hand foot mouth disease complicated with myocardial injury.Methods 100 children with hand foot mouth disease admitted to the hospital from April 2016 to January 2017 were divided into ECG normal group(n=40)and ECG abnormal group(n=60)by electrocardiography.At the same time,50 healthy people were selected as the research group to compare the serum concentration and myocardial enzyme index of myocardial enzyme(CK-MB),creatine kinase(CK),α-hydroxybutyrate dehydrogenase(α-HBDH),lactate dehydrogenase(LDH)and aspartate aminotransferase(AST),and high sensitivity cardiac troponin T(hs-cTnT)in three groups.The hs-cTnT and the indexes of myocardial enzymes in acute and recovery stages of abnormal electrocardiogram for children with hand foot mouth disease were compared.Results The indicators of CK-MB,CK,α-HBDH,LDH,AST and hs-cTnT,etc.in the ECG abnormal group of hand foot mouth disease were significantly higher than those of ECG normal group and control group.The difference was statistically significant(P<0.05).The indicators of CK-MB,CK,α-HBDH,LDH,AST and hs-cTnT,etc.in the ECG normal group of hand foot mouth disease were significantly higher than those of control group.The difference was statistically significant(P<0.05).The abnormal rate for the indicators of CK-MB,CK,α-HBDH,LDH,AST and hs-cTnT,etc.In the ECG abnormal group of hand foot mouth disease were significantly higher than those of ECG normal group and normal control group.The difference was statistically significant(P<0.05).The indicators of CK-MB,CK,α-HBDH,LDH,AST and hs-cTnT,etc.Of hand foot mouth disease ECG abnormal group in acute stage were significantly higher than those of recovery stage.The difference was statistically significant(P<0.05).Conclusion One of the serious complications in children with hand foot and mouth disease is myocardial injury.It is of great clinical value to monitor hs-cTnT and myocardial enzymes in the diagnosis of the disease.
作者
付红霞
杨靖
徐祥
FU Hongxia;YANG Jing;XU Xiang(Department of Clinical Laboratory,Taihe Hospital,Hubei University of Medicine,Shiyan, Hubei 442000,China;Department of Infectious Disease,People′s Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China;Department of Microbiology,School of Preclinical Medicine,Hubei University of Medicine,Shiyan,Hubei 442000,China)
出处
《国际检验医学杂志》
CAS
2018年第8期929-931,935,共4页
International Journal of Laboratory Medicine
基金
湖北省教育厅科学研究计划项目(B2016113)
湖北医药学院博士研究生启动金资助计划项目(2015QDJZR08)
关键词
心肌损伤
手足口病
高敏肌钙蛋白
心肌酶谱
myocardial injury
hand foot mouth disease
high sensitivity cardiac troponin T
myocardial enzymes
作者简介
付红霞,女,主管技师,主要从事病原微生物方向研究。;通信作者,杨靖,E-mail:yangjing780228@foxmail.com。
