摘要
目的探讨子宫内膜癌中热休克转录因子-1(HSF-1)蛋白的表达水平及其与患者临床病理学特征的关系。方法选取2014年1月至2016年5月在周口市妇幼保健院收集的术后或活检经病理学证实为子宫内膜癌标本67例,既往收集的35例正常子宫内膜组织,采用免疫组化染色观察两组HSF-1蛋白的表达水平,并探讨其临床病理学意义。结果子宫内膜癌组织标本中HSF-1蛋白阳性表达率71.64%(48/67),正常子宫内膜组织中HSF-1蛋白阳性表达率31.43%(11/35),两组阳性表达率比较差异有统计学意义(P<0.05);子宫内膜癌组织标本中HSF-1蛋白在高分化组织中阳性表达率86.96%高于中低分化组织的63.64%,浸润深度≤1/2肌层的阳性表达率87.50%高于≥1/2肌层的62.79%,淋巴结转移阴性组织中的阳性表达率为80.49%高于阳性组织的57.69%,均差异有统计学意义(P<0.05)。结论 HSF-1蛋白在子宫内膜癌组织中表达水平显著升高,并且与肿瘤的组织分化程度、淋巴结转移及浸润深度有关。
Objective To investigate the expression of heat shock transcription factor-1(HSF-1)protein in endometrial carcinoma and its relationship with the clinicopathological features of patients.Methods Sixty-seven cases of endometrial carcinoma who confirmed by pathology after surgery or biopsy from January 2014 to May 2016 and 35 cases of normal endometrium were collected in Zhoukou Maternal and Child Health Hospital.The expression levels of HSF-1 protein between two groups were observed by immunohistochemical staining to explore its clinical pathological significance.Results The positive expression rate of HSF-1 protein in endometrial carcinoma tissues was 71.64%(48/67),the positive expression rate of HSF-1 protein in the normal endometrium was 31.43%(11/35),and the positive expression rate of two groups was statistically significant difference(P<0.05);the positive expression of HSF-1 protein expression in endometrial cancer tissues,well differentiated tissues(86.96%)was higher than that in low differentiation tissue(63.64%),and infiltration depth≤1/2(87.50%)was higher than infiltration depth≥1/2(62.79%),negative tissues with lymph node metastasis(80.49%)was higher than 57.69%of the positive tissue with lymph node metastasis,the differences were statistically significant(all,P<0.05).Conclusions The expression level of HSF-1 protein in endometrial carcinoma tissue was significantly increased,and it was related to the degree of differentiation,lymph node metastasis and invasion depth of the tumor.
作者
董丽涛
DONG Litao(Department of Obstetrics and Gynecology,Zhoukou Maternal and Child Health Hospital,Zhoukou,Henan 466000,China)
出处
《安徽医药》
CAS
2018年第5期897-900,共4页
Anhui Medical and Pharmaceutical Journal
关键词
宫内膜癌
热休克转录因子-1
病理学特征
endometrial carcinoma
heat shock transcription factor-1
pathological characteristics
