摘要
目的比较研究奥卡西平、丙戊酸钠治疗儿童癫痫局灶性发作的临床疗效、安全性。方法入组对象为方便选取该院在2014年10月—2017年10月期间收治的60例局灶性发作癫痫患儿,这60例患儿被随机分为2组,30例每组,对照组给予丙戊酸钠治疗,观察组给予奥卡西平,比较两组临床疗效、不良反应发生率。结果观察组的临床总有效率为93.33%,对照组为73.33%,观察组高于对照组(P<0.05);在不良反应方面,观察组、对照组的发生率分别为3.33%、20.00%,观察组低于对照组(P<0.05)。结论采用奥卡西平治疗儿童癫痫局灶性发作的临床疗效、安全性均优于丙戊酸钠,是一种较理想的儿童癫痫治疗药物。
Objective This paper tries to comparative study the safety and clinical curative effect in the treatment of children with epilepsy focal seizures by oxcarbazepine and valproate sodium.Methods The subjects were 60 cases of focal seizures in children with epilepsy in this hospital from October 2014 to October 2017,60 patients were conveniently divided into 2 groups,with 30 cases in each group.The control group was given sodium valproate treatment,the observation group was given oxcarbazepine treatment,the clinical curative effect and the incidence of adverse reaction were compared between the two groups.Results The clinical total effective rate in the observation group was 93.33%,the control group was 73.33%,the observation group was higher than the control group(P<0.05);in the aspect of adverse reactions,the incidence rates in the observation group and the control group were 3.33%,20.00%,the observation group was lower than the control group(P<0.05).Conclusion The clinical curative effect and safety of oxcarbazepine in the treatment of children with epilepsy are better than seizures sodium valproate,is an ideal drug for the treatment of epilepsy in children.
作者
钟羽
陈斌
刘世凯
ZHONG Yu;CHEN Bin;LIU Shi-kai(Department of Pediatrics,Qinzhou First People’s Hospital,Qinzhou,Guangxi,535000 China)
出处
《中外医疗》
2018年第5期136-137,143,共3页
China & Foreign Medical Treatment
关键词
癫痫
局灶性发作
奥卡西平
丙戊酸钠
Epilepsy
Focal seizures
Oxcarbazepine
Sodium valproate
作者简介
钟羽(1984-),女,广西合浦人,本科,主治医师,研究方向:儿童神经系统疾病研究,侧重癫痫。
