摘要
目的研究结肠癌中神经纤毛蛋白-1(Neuropilin-1,NRP-1)的表达,并探讨其与预后的关系。方法收集我院具有随访资料结肠癌石蜡标本58例,采用免疫组化法检测结肠癌及癌旁组织中NRP-1的表达,并采用KaplanMeier方法分析NRP-1表达的高低与患者预后的关系。结果免疫组化结果显示,结肠癌组织中NRP-1表达明显高于癌旁组织(t=2.464,P=0.017);NRP-1阳性表达患者32月生存率显著低于阴性表达患者(χ~2=6.832,P=0.009)。结论NRP-1的高表达参与结肠癌的发生及发展,并导致患者预后不佳。
Objective To investigate the expression of Neuropilin-1(NRP-1)in colon cancer and explore its relationship with prognosis.Methods 58 cases of colon cancer paraffin-embedded specimens with follow-up data from our hospital were collected.The expression of NRP-1 in colon cancer tissues and paracancerous tissues were detected by immunohistochemistry,and the relationship between the expression of NRP-1 and the prognosis of patients was analyzed by Kaplan-Meier method.Results Immunohistochemistry results showed that the expression of NRP-1 in colon cancer tissues was significantly higher than that in paracancerous tissues(t=2.464,P=0.017).The 32-month survival of NRP-1 positive expression was significantly lower than that of NRP-1 negative expression(χ2=6.832,P=0.009).Conclusion The high expression of NRP-1 is involved in the occurrence and development of colon cancer and leads to poor prognosis.
作者
王辉
谢荣俊
刘龙飞
李峰
Wang Hui;Xie Rongjun;Liu Longfei(Gastrointestinal Surgery Department,Affiliated Nanhua Hospital,University of South China,Hengyang 421002)
出处
《中国现代医药杂志》
2018年第3期1-3,共3页
Modern Medicine Journal of China
基金
湖南省卫生计生委科研计划项目(编号:C2017019)
衡阳市科技计划项目(编号:2016KS09)
作者简介
通讯作者:李峰,E-mail:lifeng8448@126.com
