摘要
肾纤维化是各种慢性肾脏病进展至终末期肾病的病理基础,可危及生命。其发病机制较为复杂,由多种细胞因子和信号通路共同参与。目前尚无有效治疗药物。近年来基于肾纤维化的中医理论及其分子机制,通过随机多中心临床研究以及体内外基础研究,证实多种中药及其有效成分有延缓肾纤维化的疗效,并明确了作用靶点。继续寻找有效的延缓肾纤维化的中药,证实其疗效,明确作用机制尤为重要。
Renal fibrosis is the pathological basis of the progression of various chronic renal diseases to end stage renal disease,which is life threatening.Its pathogenesis is complex and is involved in a variety of cytokines and signaling pathways,and there is no effective therapeutic drug until now.In recent years,on the basis of TCM theory of renal fibrosis and its molecular mechanism,through randomized multicenter clinical study and basic research in vitro and in vivo,our hospital confirmed that a variety of Chinese herbs and their effective components have the effect of delaying renal fibrosis,and we have identified their action target.In a word,we should continue to find effective Chinese medicine that can postpone renal fibrosis,to confirm their curative effect,especially to clear their action mechanism.
作者
何伟明
刘不悔
高坤
周栋
盛梅笑
张露
江燕
李正红
孙伟
HE Wei-ming;LIU Bu-hui;GAO Kun;ZHOU Dong;SHENG Mei-xiao;ZHANG Lu;JIANG Yan;LI Zheng-hong;SUN Wei(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,210029,China;Medical School of University of Pittsburgh,Pittsburgh,15106,USA)
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2018年第2期112-117,共6页
Journal of Nanjing University of Traditional Chinese Medicine
基金
国家自然科学基金(81774269
81673912)
关键词
肾间质纤维化
中医药
单味中药
中药复方制剂
renal interstitial fibrosis
Chinese medicine
single Chinese medicine
Chinese medicine compound preparation
作者简介
何伟明（1972-），男，副主任中医师，博士。;通信作者：孙伟，男，主任医师，博士生导师，主要从事中西医结合治疗肾病研究，E-mail：jssunwei@163.com
