摘要
背景:近年来,人脐带华通氏胶间充质干细胞由于其来源广泛、取材简便、具有强大的自我更新和多向分化潜能,低免疫原性以及不涉及伦理学争议等特点,成为再生医学领域一类热门的种子细胞。目的:综述近5年来国内外诱导人脐带华通氏胶间充质干细胞定向分化的研究进展。方法:由第一作者在2017年1月检索了Pub Med数据库和中国知网数据库,检索词为Wharton jelly derived mesenchymal stem cell,human umbilical cord mesenchymal stem cell,differentiation,脐带华通氏胶间充质干细胞或人脐带间充质干细胞,分化。文献检索的时间范围为2012年1月至2017年1月,语言种类为英文和中文,文献类型包括论著和综述。共查到120篇文献,根据纳入标准选择46篇文献纳入研究。结果与结论:目前国内外文献中记载的由人脐带华通氏胶间充质干细胞定向分化成的细胞种类已达18余种。在近5年的文献报道中,一部分研究改进了之前的诱导方法;另一部分研究开拓了人脐带华通氏胶间充质干细胞定向分化的新方向;还有部分研究初步探索了分化过程中涉及的信号通路及相关的分子机制。分化后的脐带华通氏胶间充质干细胞可用于人体多部位组织细胞的再生、修复治疗,在不久的将来会给许多目前难以治愈的疾病带来希望。
BACKGROUND:In recent years,because of its wide range of sources,easy access,strong self-renewal capacity,multi-directional differentiation potential,low immunogenicity and low ethical controversy and other characteristics,human Wharton’s Jelly-derived mesenchymal stem cells have become popular seed cells in regenerative medicine.OBJECTIVE:To review the advances in directional differentiation of human Wharton’s Jelly-derived mesenchymal stem cells in recent five years.METHODS:The PubMed and CNKI databases were searched by the first author using the keywords of“Wharton Jelly derived mesenchymal stem cell,human umbilical cord mesenchymal stem cell,differentiation”in English and Chinese,respectively.The retrieval time was from January 2012 to January 2017.After initial search,120 articles were collected,and 46 articles were included in final analysis.RESULTS AND CONCLUSION:Up to now,there are more than 18 types of cells that have been differentiated from Wharton’s Jelly-derived mesenchymal stem cells.In recent 5 years,some studies have improved the previous induction method,some studies have developed the new directional differentiation of Wharton’s Jelly-derived mesenchymal stem cells,and the others have explored the involved signal pathways and relevant molecular mechanisms.Differentiated Wharton’s Jelly-derived mesenchymal stem cells can be used for human tissue regeneration and repair,which give hope to the treatment of many refractory diseases.
作者
施沁
杨晓清
张玉泉
Shi Qin;Yang Xiao-qing;Zhang Yu-quan(epartment of Obstetrics and Gynecology,Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2018年第5期793-800,共8页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金面上项目(81370677)~~
作者简介
施沁，女，1993年生，江苏省南通市人，汉族，南通大学医学院妇产科学在读硕士，主要从事妇科生殖领域的相关研究。;通讯作者：张玉泉，博士，主任医师，南通大学附属医院妇产科，江苏省南通市226001
