摘要
目的探讨丁酰胆碱酯酶(butyrocholinesterase,BChE)基因K变异与老年非心脏手术术后谵妄的关系。方法采用连续入组方法,将2014年1月至2016年12月山东省立医院100例老年非心脏手术术后谵妄患者纳入谵妄组,108例非谵妄患者纳入非谵妄组,检测两组患者血清BChE活性,采用聚合酶链反应及直接测序法测定BCHE基因K变异基因型,并分析BChE不同基因型与BChE活性的相关性。结果谵妄组患者BChE活性明显低于非谵妄组(P<0.05),两组BChE基因型及等位基因分布无显著差异(P>0.05)。不同基因型BChE活性组内比较差异无显著性(P>0.05)。结论 BCHE基因K变异与老年非心脏手术术后谵妄无明显相关性。
Objective To investigate the relationship between butyrocholinesterase(BChE)gene K variant and postoperative delirium in elderly patients undergoing noncardiac surgery.Method From January 2014 to December 2016,100 elderly patients with delirium after non-cardiac surgery in Shandong Provincial Hospital Affiliated to Shandong University were included in delirium group,108 patients without delirium were included in non-delirium group,and the serum BChE activity in the two groups was detected.BChE gene K variant was detected by PCR and direct sequencing method.At the same time,the relationship between BChE genotypes and activities was analyzed.Result Delirium group patients had lower BChE activity than non-delirium group patients(P<0.05).Genotype distributions and allele frequencies of BCHE gene didn't different between the two groups(P>0.05).There was no significant difference in the activity of BChE between different genotypes(P>0.05).Conclusion BCHE gene K variant is not associated with susceptibility to postoperative delirium in elderly patients.
作者
倪玉华
赵宝
邢志群
NI Yu-hua;ZHAO Bao;XING Zhi-qun(Department of Healthcare,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250014,China;Department of SICU,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250014,China;Department of Critical Care Medicine,Peking Union Medical College Hospital,Beijing 100730,China)
出处
《中国医学前沿杂志（电子版）》
2018年第1期62-65,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
山东省自然基金青年基金项目(ZR2013HQ032)
关键词
丁酰胆碱酯酶
基因多态性
术后谵妄
Butyrocholinesterase
Gene polymorphism
Postoperative delirium
作者简介
通讯作者:倪玉华E-mail:niyuhua1980@163.com
