摘要
目的探讨血清脂蛋白磷脂酶A2(Lp-PLA2)对良性前列腺增生(BPH)筛查诊断的临床价值。方法选取临床确诊为BPH的65例血清作为BPH组,64例健康男性的血清作为对照组,分别检测两组血清中Lp-PLA2、总前列腺特异性抗原(tPSA)与游离前列腺特异性抗原(fPSA)的水平,并利用ROC曲线分析LpPLA2与F/T值对BPH诊断的特异性与敏感性。结果 BPH组血清中Lp-PLA2、tPSA与fPSA的水平明显高于对照组,差异有统计学意义(P<0.05)。ROC曲线分析发现,Lp-PLA2的曲线下面积(AUC)为0.763,95%置信区间(CI)为0.680~0.833;F/T比值的AUC为0.715,95%CI为0.633~0.795;Lp-PLA2联合F/T比值的AUC为0.832,95%CI为0.756~0.892。结论血清Lp-PLA2可作为BPH的筛查指标,且其联合F/T比值对BPH的诊断效果比单项指标效果好。
Objective To investigate the clinical value of serum lipoprotein associated phospholipase A2(Lp-PLA2)as a biomarker for benign prostatic hyperplasia(BPH).Methods A total of 65 serum samples of BPH patients were selected as BPH group,64 serum samples of healthy male as control group.The serum level of Lp-PLA2,total prostate specific antigen(tPSA)and free prostate specific antigen(fPSA)in both groups were detected,and the specificity and sensitivity of Lp-PLA2,F/T ratio and combine both were analyzed by ROC curve.Results The serum level of Lp-PLA2,tPSA and fPSA in BPH group were significantly higher than those in control group,the different were significant(P<0.05).ROC curve analyze shown that the area under the curve(AUC)of Lp-PLA2 was 0.763,95%confidence interval(CI)was 0.680-0.833;AUC of F/T ratio was 0.715,95%CI 0.633-0.795;AUC of Lp-PLA2 combined with F/T ratio was 0.832,95%CI 0.756-0.892.Conclusion The serum level of Lp-PLA2 could be used as a potential diagnostic marker for BPH,and the diagnostic value of Lp-PLA2 combined with F/T ratio was better than ther single indicator.
作者
杨华文
刁志宏
王婷
邱厚匡
魏彦琪
张智
花文峰
YANG Huawen;DIAO Zhihong;WANG Ting;QIU Houkuang;WEI Yanqi;ZHANG Zhi;HUA Wenfeng(Department of Laboratory Medicine,Guangdong Second Provincial General Hospital,Guangzhou,Guangdong 510317,China)
出处
《国际检验医学杂志》
CAS
2018年第4期447-449,共3页
International Journal of Laboratory Medicine
基金
广东省第二人民医院引进人才科研启动基金项目(YY2016-004)
作者简介
杨华文，男，主管技师，主要从事生化与微生物检验的研究。;通信作者，E-mail:huawf@gd2h.org.cn。
