摘要
目的分析儿童急性淋巴细胞白血病化疗后不良反应发生的特点及规律,实施个体化给药避免或减少严重的药品不良反应(ADR)的发生.方法收集2014年3月至2015年2月新发儿童急性淋巴细胞白血病化疗后不良反应184 3例,对患者性别,年龄,危险度、药物、ADR累及器官或系统等方面进行研究分析.结果儿童急性淋巴细胞白血病化疗后不良反应涉及高危组患者居多;涉及药物以左旋门冬酰胺酶、长春新碱、阿糖胞苷居前3位;不良反应累及的系统或器官以血液系统最为常见;骨髓抑制并发感染与危险度及患儿年龄差异有统计学意义(P<0.01),与性别无统计学差异(P>0.05).结论儿童急性淋巴细胞白血病化疗后ADR以骨髓抑制最为常见,其中以骨髓抑制及并发感染对患儿生活质量及治疗效果的影响最大.
Objective To analyse the characteristics of adverse reactions in children with acute lymphoblastic leukemia after chemotherapy,and to implement individualized medication to avoid or reduce the occurrence of serious adrs.Methods The report on the adverse reactions in children with acute lymphoblastic leukemia after chemotherapy from2015.2to2014.3was collected,the patient gender,age,risk,drug and ADR involving organs or systems were analyzed.Results The adverse reactions in children with acute lymphoblastic leukemia after chemotherapy are involved mostly in the high-risk group of patients.L-asparaginase,vincristine and cytarabine were the top three drugs involved in adverse reactions.Blood system was the most common system involved in adverse reactions.Bone marrow suppression concurrent infection had significant difference between different risks and ages(P<0.01)had no statistical difference between different genders(P>0.05).Conclusion Bone marrow suppression was the most common ADR in children with acute lymphoblastic leukemia after chemotherapy,and bone marrow suppression and concurrent infection have the greatest influence on the quality of life and the treatment effect of children.
作者
孙建明
董芳
SUN Jian-ming;DONG Fang(Dept. of Pharmacy,Children’s Hospital Affiliated to Kunming Medical University,Yunnan Kunming650034;Retired Veteran Cadres Hospiital in Yunnan,Kunming Yunnan 650011,China)
出处
《昆明医科大学学报》
CAS
2017年第10期107-111,共5页
Journal of Kunming Medical University
基金
昆明市卫生科技人才培养项目暨"十百千"工程基金资助项目[(SW(后备)76)]
作者简介
孙建明（1974～），男，云南易门县人，大学本科，副主任药师，主要从事临床药学工作.;通信作者,董芳．E-mail:sunjianming@etyy.cn
