摘要
通过冷冻干燥法制备羟丙基-β-环糊精和格列美脲包合物,用相溶解度法测定格列美脲和羟丙基-β-环糊精的包合常数,并用紫外光谱、红外光谱(FTIR)和~1H NMR对包结物进行验证.结果表明,格列美脲和羟丙基-β-环糊精形成1:1的可溶性包合物,25°C时包合稳定常数为2140.9L·mol^(-1),形成包合物后格列美脲的水溶性增强近七倍.
Gliepiride-hydroxypropyl-β-cyclodextrin inclusion complex(GP-HPCD)was prepared by the method of freeze drying.The stability constant was determined by the experiment of phase solubility.The inclusion complex was verified by Ultraviolet spectrum(UV),Fourier transform infrared spectroscopy(FTIR)and1H NMR.It was found that the formation of the soluble inclusion complex with1:1molar ratio of gliepiride and hydroxypropyl-β-cyclodextrin,and the stability constant was2140.9L·mol-1at25°C by the experiment of phase solubility.The solubility experiment of the inclusion complex indicated that the solubility of gliepiridein in the inclusion complex increased7-fold.
作者
朱庆英
卓晓婵
ZHU Qingying;ZHUO Xiaochan(School of Chemistry and Material Engineering,Huizhou University Huizhou 5160007,Guangdong,China)
出处
《惠州学院学报》
2017年第3期47-51,共5页
Journal of Huizhou University
基金
惠州学院自然科学研究项目(hzux1201511)
关键词
格列美脲
羟丙基-Β-环糊精
包合物
相溶解度
glimepiride
hydroxypropyl-β-cyclodextrin
inclusion complex
phase solubility
作者简介
朱庆英（1975 - ），女，江苏宜兴人，讲师，博士，研究方向为超分子化学反应，E-mail: 1378094994@qq.com
