摘要
目的了解嗜水气单胞菌的产酶现状和耐药性,为临床治疗嗜水气单胞菌的感染提供合理用药的依据。方法收集2011~2015年,从临床感染标本中分离出嗜水气单胞菌50株。常规药敏试验采用K-B纸片法,超广谱β-内酰胺酶(ESBLs)依据2012年CLSI标准双纸片确证试验,头孢菌素酶(AMPC)应用三维试验改良法。结果感染的50株嗜水气单胞菌,其中产ESBLs 15株(15/50)、产AMPC 10株(10/50),且对氨苄西林全部耐药、对氨苄西林/舒巴坦钠耐药率为94%,对三、四代头孢菌素耐药率达40%,对其他药物保持较高的敏感性。结论临床治疗嗜水气单胞菌引起感染时,应慎用头孢菌素类药物,根据药敏结果和耐药表型合理选用药物,为临床用药提供依据。
Objective To understand the current enzyme production and drug resistance of A.hydrophila forclinical treatment of A.hydrophila infection and to provide the basis for the rational use of antibiotics.Methods Fifty strains of A.hydrophilabacteria were collected from clinical specimens from2011to2015.The routine drug sensitivity test was carried out using the K-B paper method,and the extended-spectrumβ-lactamases(ESBLs)was confirmed by the CLSI standard double disk tests.The AMPC was detected by three-dimensional test.Results Among50strains of A.hydrophila,15strains produced ESBLs and10strains produced AMPC.All bacteria showed ampicillin resistance.Ampicillin/sulbactam resistant rate was94%,and the third and the fourth generation cephalosporin resistant rate was40%although the other antibiotics remained highly sensitive.Conclusion Clinical treatment of A.hydrophila infection should be careful with cephalosporins so as to improve the efficacy of antibiotics.
作者
扈会整
李俊海
张晔婷
任伟娟
文杏
王婵
HU Hui-zheng;LI Jun-hai;ZHANG Ye-Ting(No. 215 Hospital of Xi'an Medical College ,Xi'an)
出处
《临床输血与检验》
CAS
2017年第5期460-461,共2页
Journal of Clinical Transfusion and Laboratory Medicine
基金
陕西省科学技术研究发展计划项目(No.2014K11-02-03-09)资助
作者简介
扈会整（1977–），女，副主任检验师，硕士，主要从事微生物的检验与研究工作，（Tel）15384509179（E-mail）gj176224042@163.com。
