摘要
目的:探讨罗氏e601免疫分析仪检测分化型甲状腺癌患者术前血清甲状腺球蛋白(Tg)、抗甲状腺球蛋白抗体(ATG)及促甲状腺激素(TSH)水平及其临床预测价值。方法:抽取在医院住院接受手术治疗的244例甲状腺结节患者,以病理结果作为甲状腺结节性质诊断的金标准,将其中符合分化型甲状腺癌患者分为甲状腺癌组(110例);符合良性结节的患者分为良性结节组(134例);同期抽取医院健康体检中心健康人员分为健康对照组(100名)。采用罗氏e601免疫分析仪检测3组研究对象血清Tg、TAb及TSH水平。结果:3组检测血清Tg、Tg Ab及TSH水平差异均有统计学意义(F=28.645,F=68.258,F=13.286;P<0.01);甲状腺癌组血清Tg水平明显高于良性结节组和健康对照组,差异有统计学意义(t=21.967,t=241.808;P<0.01);甲状腺癌组血清Tg Ab水平明显高于良性结节组和健康对照组,差异均有统计学意义(t=36.814,t=46.281;P<0.01);甲状腺癌组血清TSH水平明显高于良性结节组和健康对照组,差异均有统计学意义(t=13.585,t=24.256;P<0.01);3组研究对象血清Tg、Tg Ab及Tg联合Tg Ab阳性率比较,差异均有统计学意义(x^2=124.00,x^2=43.246,x^2=90.737;P<0.01);甲状腺癌组、良性结节组血清Tg、Tg Ab及Tg联合Tg Ab阳性率均高于健康对照组(x^2=31.777,x^2=37.228,x^2=113.605;x^2=37.632,x^2=12.722,x^2=53.456;P<0.01),血清Tg阳性率,甲状腺癌组与良性结节组比较,差异无统计学意义(x^2=0.169,P>0.05),Tg Ab及Tg联合Tg Ab阳性率甲状腺癌组与良性结节组比较,差异有统计学意义(x^2=13.050,x^2=7.950;P<0.01);Logistic回归分析显示,血清Tg Ab阳性、血清TSH升高是分化型甲状腺癌的危险因素(OR=0.321,OR=0.192;P<0.05)。结论:分化型甲状腺癌患者术前血清Tg Ab阳性、TSH升高是分化型甲状腺癌的危险因素,血清Tg Ab及TSH水平对分化型甲状腺癌的术前诊断具有一定临床意义。
Objective:To investigate the detection results of Roche E601for preoperative Tg,Tg Ab and TSHof patient with differentiated thyroid carcinoma and their predictive value in clinical diagnosis.Methods:Asthe diagnostic gold standard of thyroid nodule,pathological examination,244patients with thyroid nodule weredivided into thyroid cancer group(110cases)and benign nodule group(134cases).At the same time,100personswho were determined as health persons in physical examination were divided into health group.The serum levelof Tg,Tg Ab and TSH of them were detected by using Roche E601that was a kind of immune analysis meter.Results:The differences of Tg,Tg Ab AND TSH among the three groups were statistically significant(F=28.645,F=68.258,F=13.286;P<0.01),respectively.The results of serum Tg of thyroid cancer group was,respectively,statistically significant higher than that of other two group(t=21.967,t=241.808;P<0.01).And the serum Tg Ab ofthyroid cancer group also was,respectively,statistically significant higher than that of other two group(t=36.814,t=46.281;P<0.01).And the serum TSH of thyroid cancer group was,respectively,statistically significant higherthan that of other two groups(t=13.585,t=24.256;P<0.01).The differences of positive rate of serum Tg,Tg Aband Tg combined with Tg Ab were statistically significant(x2=124.00,x2=43.246,x2=90.737;P<0.01).And thepositive rates of serum Tg,Tg Ab and Tg combined with Tg Ab of thyroid cancer group and benign nodule groupwere,respectively,higher than that of health group(x2=31.777,x2=37.228,x2=113.605,x2=37.632,x2=12.722,x2=53.456;P<0.01).Besides,the difference of positive rate of serum Tg between thyroid cancer group and benignnodule group was no statistically significant(x2=0.169,P>0.05).However,the difference of positive rate of serum TgAb and Tg combined with Tg Ab between thyroid cancer group and benign nodule group were statistically significant(x2=13.050,x2=7.950,P<0.01).The results of Logistic regression analysis indicated that the positive serum Tg Aband the increased serum TSH were hazards factors of differentiated thyroid carcinoma(OR=0.321,OR=0.192;P<0.05).Conclusion:The preoperative positive rate of serum Tg Ab and increasing of serum TSH of patients withdifferentiated thyroid carcinoma were the hazards factors of differentiated thyroid carcinoma,and serum Tg Ab andTSH have clinical significance in preoperative diagnosis of differentiated thyroid carcinoma.
作者
张雷
何流
龙佩
颜露
刘春燕
经继生
ZHANG Lei;HE Liu;LONG Pei(Clinical Laboratory, People's Hospital of Guang'an, Guang'an 638000, China)
出处
《中国医学装备》
2017年第10期97-100,共4页
China Medical Equipment
关键词
分化型甲状腺癌
e601免疫分析仪
甲状腺球蛋白
抗甲状腺球蛋白抗体
促甲状腺激素
Differentiated thyroid carcinoma
E601 immunoassay analyzer
Thyroglobulin(Tg)
Anti thyroglobulin antibody (Tg Ab)
Thyroid stimulating hormone (TSH)
作者简介
张雷,男,(1982-),本科学历，主管技师。广安市人民医院检验科，研究方向：免疫检验
