摘要
目的观察分析氟西汀联合抗精神病药物治疗伴有强迫症状精神分裂症患者的临床效果。方法选择104例伴有强迫症状精神分裂症患者作为研究对象,采用随机数字抽取表法将患者分为观察组和对照组,每组52例。给予对照组患者采用单纯抗精神药物治疗措施,给予观察组在对照组治疗的基础上增加氟西汀治疗,对两组患者治疗4周和8周后的临床疗效、阳性和阴性症状评分、生活质量评分、强迫症状评分及不良反应发生情况等进行比较。结果观察组治疗总有效率为94.23%,显著高于对照组患者治疗总有效率76.93%,数据比较差异具有统计学意义(P<0.05);观察组和对照组患者的阳性和阴性症状评分治疗前、治疗4周、治疗8周评分分别为(98.23±15.36)、(71.23±8.52)、(50.08±6.68);(97.52±15.33)、(83.69±8.87)、(71.22±6.52);生活质量治疗前、治疗4周、治疗8周评分分别为(38.53±7.25)、(50.12±3.52)、(55.96±3.46),(38.82±7.17)、(42.63±3.17)、(47.08±3.39);强迫症状治疗前、治疗4周、治疗8周评分分别为(20.09±5.63)、(13.66±3.32)、(10.19±3.41),(20.05±5.82)、(17.42±3.76)、(15.88±3.37),治疗后均显著优于治疗前,且治疗4周阶段和治疗8周阶段观察组患者的阳性和阴性症状评分、生活质量评分、强迫症状评分均显著优于对照组,数据比较差异具有统计学意义(P<0.05)。结论对伴有强迫症状精神分裂症患者在抗精神病药物治疗上联合氟西汀治疗具有显著的疗效,能够有效改善患者的精神症状和强迫症状,提高患者的生活质量。
Objective To observe the clinical effect of fluoxetine combined with anti psychiatry drug in the treatment of obsessive-compulsivesymptoms in schizophrenic patients.Methods104cases with selection of our hospital for treatment of obsessive-compulsive symptoms of schizophreniapatients as the research object,according to the random number table extraction method were divided into the observation group and controlgroup,52cases in each group.The control group were treated by simple antipsychotic drug treatment,the observation group was given fluoxetine increasedin the control group based on the treatment of two groups of patients treated for4weeks and8weeks after the clinical curative effect of positiveand negative symptoms.Like the score,life quality score,compare the obsessive-compulsive symptom scores and the incidence of adverse reactions.Results The total effective rate of observation group was94.23%,significantly higher than the control group in the total efficiency of76.93%,with significant data difference(P<0.05);The observation group and the control group of patients with positive and negative symptom scores beforetreatment,4weeks and8weeks of treatment were respectively(98.23±15.36),(71.23±8.52),(50.08±6.68);(97.52±15.33),(83.69±8.87),(71.22±6.52);quality of life before treatment,4weeks and8weeks of treatment were respectively(38.53±7.25),(50.12±3.52),(55.96±3.46),(38.82±7.17),(42.63±3.17),(47.08±3.39);obsessive-compulsive symptoms before treatment,4weeks and8weeks of treatment were respectively(20.09±5.63),(13.66±3.32),(10.19±3.41),(20.05±5.82),(17.42±3.76),(15.88±3.37),after treatment were significantly better than before treatment,and the treatmentof4weeks and8weeks of treatment stage stage of observation group of patients with positive and negative symptom score and life qualityscore,obsessive-compulsive symptom scores were significantly better than the control group,with statistically significant data difference(P<0.05).Conclusion The obsessive-compulsive symptoms in patients with schizophrenia antipsychotic treatment combined with fluoxetine in the treatmenthas significant curative effect,can effectively improve the patients with psychiatric symptoms and obsessive-compulsive symptoms,improve thequality of life of patients.
作者
邹果果
黄弋瑾
陈筱章
Zou Guo-guo;Huang Yi-jin;Chen Xiao-zhang(The third people's hospital of psychiatric yi chun city, Yichun, Jiangxi, 336000,China;The third people's hospital medical yichun city, Yichun, Jiangxi, 336000, China)
出处
《当代医学》
2017年第26期27-29,共3页
Contemporary Medicine
