摘要
目的:探讨bcl-2和bax蛋白的表达与鼻咽癌放射敏感性的关系。方法:应用免疫组化法检测51例放疗前鼻咽癌活检组织中bcl-2和bax蛋白的表达。结果:51例鼻咽癌组织中bcl-2和bax蛋白表达阳性者均为47例(92.2%);鼻咽癌组织中bcl-2和bax蛋白的表达强度呈显著相关(P<0.05);bcl-2蛋白的表达与鼻咽癌放射敏感性呈负相关(P<0.05),而bax蛋白的表达与鼻咽癌放射敏感性无关(P>0.05);bcl-2/bax的比率与鼻咽癌放射敏感性呈负相关(P<0.05)。结论:bcl-2蛋白和bcl-2/bax的比率是反映鼻咽癌放射敏感性和预测鼻咽癌放疗效果的重要指标,而bax蛋白不能单独作为判断鼻咽癌放射敏感性的指标。
Objective: To investigate the relationship between the expression of bcl-2 and bax protein and the radiosensitivity of nasopharyngeal carcinoma(NPC). Methods: The expression of bcl-2 and bax protein was detected by immunohistochemical method in 51 biopsy specimens prior to radiotherapy of NPC. Results: The positive expression of bcl-2 and of bax protein were both demonstrated in 47 out of 51 cases(92.2%)of NPC. The positive expression between bcl-2 and bax protein was highly correlated(P<0.05). The bcl-2 protein expression was negatively correlated with the radiosensitivity of NPC(P<0.05), while the bax protein expression was not correlated with the radiosensitivity of NPC(P>0.05). There was a negatively correlation between bcl-2/bax ratio and the radiosensitivity of NPC (P<0.05). Conclusion: The bcl-2 protein and the bcl-2/bax ratio were the important parameters reflecting the radiosensitivity and predicting the radiotherapeutic effect of NPC, while the bax protein could not be taken as an independent parameter to predict radiosensitivity of NPC.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2004年第18期35-37,共3页
Chinese Journal of Clinical Oncology
基金
广东省科技计划基金资助(编号:2002C30316)
