摘要
目的:比较中药虎杖不同提取物的活血化淤功能。方法:收集虎杖提取过程中的水煎液提取物、水提醇沉提取物、碱水渗漉醇沉提取物,以高、低剂量对小鼠灌胃给药7 d后,眼眶取血,测定血浆活化部分凝血活酶时间(Activated Partial Thromboplastin Time、APTT)、凝血酶原时间(Prothrombin Time、PT)及纤维蛋白原含量(Fi-brinogen、FIB)。结果:虎杖三种提取物均能延长APTT、PT时间及降低FIB的含量,其中水煎液提取物随着剂量增加能显著的延长血浆APTT、PT时间,降低FIB含量,和其他组具有统计学意义。结论:虎杖水煎液提取物比其他提取物具有更显著的活血化淤作用。
Objective:To compare the effect of activating blood circulation to dissipate blood stasis of different extracts from polygonum cuspidatum sieb.et zucc.Methods:Decoction extract,aqueous extract of alcohol,alkaline shenlu alcohol extract were collected from polygonum cuspidatum.Mices were respectively administered intragastrically with the high dose and the low dose of the three kind of extracts.After severn days,the blood from eye sockets was collected and detected its APTT、PT、FIB.Results:Three kind of extracts all could prolong the APTT、PT and reduce the level of FIB.Compared with the other extracts,the decoction extract could obviously prolong the APTT、PT and decrease the level of FIB with the dose increase.Conclusion:The decoction extract of Giant Knotweed Rhizome have more significant effect of activating blood circulation to dissipate blood stasis than the other extracts.
出处
《临床医药实践》
2010年第6X期713-716,共4页
Proceeding of Clinical Medicine
关键词
虎杖
活血化瘀
提取物
Polygonum
promoting blood circulation
extracts
