摘要
目的探讨益肾清热利湿法对下焦湿热型Ig A肾病患者中医证候及血清炎症因子的影响。方法选取我院收治的下焦湿热型Ig A肾病患者72例,依据随机数字表法分为对照组与治疗组,各36例。对照组给予常规治疗,治疗组在对照组的基础上应用益肾清热利湿法,2组患者进行为期3个月的治疗。比较2组患者治疗前后下焦湿热型中医证候积分、α1-微球蛋白(α1-MG)、视黄醇结合蛋白(RBP)、β2-微球蛋白(β2-MG)、血清炎性因子、24小时尿蛋白定量和尿红细胞计数变化情况,并计算临床总有效率。结果治疗组中医证候积分降低较对照组更为明显(P <0.05);治疗组α1-MG、RBP、β2-MG水平较对照组降低更为明显(P <0.05);治疗组TNF-α、IL-6、IL-15水平较对照组降低更为明显(P <0.05);治疗组24小时尿蛋白定量和尿红细胞计数较对照组降低更为明显(P <0.05);治疗组临床总有效率为88.89%,优于对照组的66.66%(P <0.05)。结论益肾清热利湿法可以改善下焦湿热型Ig A肾病患者临床症状和体征,有较好的的治疗效果。
Objective To investigate the ef fect of tonifying kidney,clearing heatand promoting diuresis on TCM syndromes and serum inflammatory factors of IgA nephropathy patients with damp-heat in lower jiao.Methods 72 IgA nephropathy patients with damp-heat in lower jiao admitted to our hospital were selected and randomly divided into treatment group and control group with 36 cases in each group according to the table of random number.The control group was given routine treatment,while the treatment group was treated with the method of tonifying kidney,clearing heat and promoting diuresis on the basis of the control group,both groups of patients were treated for 3 months.The TCM symptom scores of damp-heat in lower jiao,the level of alpha 1-microglobulin(α1-MG),retinol binding protein(RBP),beta 2-microglobulin(β2-MG),and serum inflammatory factors,the changes of 24-hour urinary protein quantitation and urinary red blood cell count between the two groups were compared before and after treatment,and the clinical total ef fective rate were calculated.Results The scores of TCM symptoms in both groups were decreased,the treatment group decreased significantly compared with the control group(P<0.05).The level ofα1-MG,RBP,β2-MG were significantly lower than those in the control group(P<0.05).The level of TNF-α,IL-6 and IL-15 in the treatment group were significantly lower than those in the control group(P<0.05).The 24-hour urinary protein quantitation and urinary red blood cell count in the treatment group decreased significantly than those in the control group(P<0.05).The clinical total ef fective rate were 88.89%of the treatment group and 72.22%of the control group(P<0.05).Conclusion The method of tonifying kidney,clearing heatand promoting diuresis can improve clinical symptoms and signs of IgA nephropathy patients with damp-heat of lower jiao and has a good therapeutic ef fect.
作者
李岩
远方
LI Yan;YUAN Fang(Department of Nephrology,Affi liated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)
出处
《长春中医药大学学报》
2019年第4期676-679,共4页
Journal of Changchun University of Chinese Medicine
基金
国家自然科学基金(81702622)
辽宁省自然科学基金(20170540607)
关键词
IGA肾病
中医证候
血清炎性因子
益肾清热利湿法
IgA nephropathy
TCM syndromes
serum inflammatory factor
method of tonifying kidney,clearing heat and promoting diuresis
作者简介
李岩(1979-),女,硕士,主治医师,主要从事慢性肾脏病的中西医结合治疗研究;通信作者:远方,女,主任医师,硕士研究生导师,电话-18840529158,电子信箱-fuxuan15@163.com
