摘要
目的研究比较阿奇霉素与诺氟沙星治疗小儿急性肠胃炎的临床效果。方法研究时间为2016年1月～2018年1月,研究对象选择98例就诊于我院儿科的小儿急性肠胃炎患儿,应用随机数字表法将98例患儿随机分为2组,49例/组,A组采用诺氟沙星治疗,B组采用阿奇霉素治疗,比较两组的临床疗效、症状缓解时间、住院时间、血清炎性因子指标、不良反应。结果 B组的临床总有效率高于A组(P <0.05),其呕吐、腹痛、腹泻、发热等症状缓解时间均短于A组(P <0.05),住院时间也短于A组(P <0.05)。治疗后,B组的CRP、IL-6、PCT均低于A组(P <0.05)。在不良反应方面,两组的总发生率比较差异无统计学意义(P> 0.05)。结论采用阿奇霉素治疗小儿急性肠胃炎的临床疗效优于诺氟沙星,可有效加快患者症状缓解,缩短其治疗时间,对其机体内炎症反应予以抑制,且不良反应较少,安全性可靠。
Objective To study and compare the clinical effects of azithromyein and norfloxaein in the treatment of acute gastroenteritis in children. Methods Ninety-eight children with acute gastroenteritis in pediatrics department of our hospital from January 2016 to January 2018 were selected,and divided into two groups according to random numbers table method,49 cases per group.Group A was treated by norfloxacin, group B was treated by azithromyein. The clinical efficacy,remission time,hospitalization time,serum inflammatory factors and adverse reactions were compared between the two groups. Results The total clinical effective rate of group B was higher than that of group A （ P 〈 0.05）.The remission time of vomiting, abdominal pain,diarrhea and fever in group B was shorter than that in group A （P 〈 0.05）,the hospitalization time was also shorter than group A （P 〈 0.05）.After treatment,CRP,IL-6 and PCT in group B were lower than those in group A （P 〈 0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups （P 〉 0.05）. Conclusion The clinical efficacy of azithromyein in the treatment of acute gastroenteritis in children is better than norfloxacin,which can effectively accelerate the relief of symptoms,shorten the treatment time,inhibit the inflammatory response in the body,and have fewer adverse reactions and reliable safety.
作者
戴毅华
叶明勇
DAI Yihua;YE Mingyong(Longchuan County Maternal and Child Health Hospital,Guangdong Province,Heyuan 517300,China)
出处
《中国医药科学》
2018年第20期48-50,共3页
China Medicine And Pharmacy
关键词
小儿急性肠胃炎
阿奇霉素
诺氟沙星
儿科
Acute gastroenteritis in ehildren
Azithromyein
Norfloxaein
Pediatries department
