摘要
国内外大量研究表明慢性心力衰竭发病率呈逐年上升趋势,并且随着年龄的增长,慢性心力衰竭发生频率不断增加,已经成为心血管领域中越来越引起人们关注的重要因素。血管紧张素家族包含诸多成员,其中最重要的是血管紧张素Ⅱ,其通过促进心肌细胞重构、凋亡、纤维化、肥大、钙超载、冠状动脉内皮细胞重塑和引起钠水潴留等分子机制引起慢性心力衰竭。慢性心力衰竭与机体血管紧张素Ⅱ水平密切相关,现就这一领域最新研究成果做一系统阐述。
A large number of studies at home and abroad show that the incidence of chronic heart failure（CHF）is increasing year by year.With an increasingly aging population,the frequency of CHF is correspondingly rising.It has become an important factor attracting more and more attention in the field of cardiovascular disease.The angiotensin family contains many members,and the most important member is angiotensin Ⅱ,which causes CHF by promoting myocardial cell remodeling,apoptosis,fibrosis,hypertrophy,calcium overload,coronary endothelial cell remodeling and sodium retention.CHF is closely related to the level of angiotensin Ⅱ in the body.This article is a systematic exposition of the latest research results in this field.
作者
王灵冰
滕欣越
张瑞
毛露
陈艾东
WANG Lingbing;TENG Xinyue;ZHANG Rui;MAO Lu;CHEN Aidong(Nanjing Medical University,Nanjing 211166,Jiangsu,China;Southeast University,Nanjing 210096,Jiangsu,China)
出处
《心血管病学进展》
CAS
2018年第6期963-966,共4页
Advances in Cardiovascular Diseases
基金
国家自然科学基金面上项目(31571168)
国家公派留学基金(20173059)
作者简介
王灵冰（1997-），本科，主要从事慢性心力衰竭发病分子机制的研究。E-mail：872298945@qq.com;通信作者：陈艾东（1978-）,主治医师，博士，主要从事心血管疾病中枢调控分子机制的研究。E-mail：aidongchen@njmu.edu.cn
