摘要
目的:探索TPS(放射治疗计划系统)-ZOOM(缩放)功能在肺肿瘤立体定向体部放射治疗(stereotactic body radiation therapy,SBRT)靶区体积勾画中的临床差异。方法:临床分析25个肺内拟行SBRT治疗的可见病灶;其中17个病灶≤3 cm,3 cm <8个病灶≤5 cm。同一个放疗医师分别在TPS-ZOOM取值为100%、150%、200%、250%、300%、400%、500%、600%、700%、800%等10组缩放图像上分别勾画GTVx=(1,1. 5,2,2. 5,3,4,5,6,7,8)每组25个GTV共计250个病灶数据信息。采用SPSS 20. 0对每一个病灶均采用Spearman行相关性分析; ANOVA方差分析检验1 0组间的勾画差异,P <0. 05为统计学有差异。结果:92%(23/25)病灶体积与缩放值大小呈负相关; 1 0组数据总体比较F=0. 178,P=0. 916,无统计学差异;分层分析≤3 cm组和> 3~5 cm组F分别为0. 176和0. 272,P值分别为0. 900和0. 980,均未见统计学差异。结论:对小于5 cm的肺部病灶,各病灶缩放值与靶区体积呈一定负相关,但总体各缩放值体积数据间未见统计学差异;因拟行SBRT的病灶体积较小,为了便于临床医师较易识别病灶边缘与勾画靶区,建议缩放150%~200%。
Objective：To explore the clinical difference of TPS-ZOOM function in the volume delineation of lung tumor SBRT target.Methods：The visible lesions of 25 lung cancer patients were analyzed clinically.17 lesions were ≤ 3 cm,3 cm 〈8 lesions ≤ 5 cm.In the 10 groups of scaling images,GTVx=（1,1.5,2,2.5,3,4,5,6,7,8） were mapped on 10 groups of 25 GTV for each group of 25 GTV,with a total value of 100%,150%,200%,250%,300%,400%,500%,600%,700%,and 800% respectively.The use of SPSS 20.0 in each focus was analyzed by spearman correlation,single factor ANOVA test showed the difference between the 10 groups,P〈0.05 was statistically significant.Results：92%（23/25） lesions were negatively correlated with different scaling values.10 groups data total comparison F value=0.178,P=0.916 was not statistically significant.The F values of the lesion ≤3 cm group and 〉3~5 cm group were 0.176 and 0.272 respectively.The P values were 0.900 and 0.980 respectively,and no significant difference was found.Conclusion：In the case of lung lesion less than 5 cm,GTV showed a general negative correlation with the scaling of TPS-ZOOM,but no significant statistical difference was observed in the overall scaling group.However,because of the small size of the lesion GTV in the treatment of SBRT in the lung,it is easier for clinicians to identify the lesion edge of the lesion and suggest a scale of 150% to 200%.
作者
贺选
高红祥
张双燕
张军维
张学成
He Xuan;Gao Hongxiang;Zhang Shuangyan;Zhang Junwei;Zhang Xuecheng(Department of Radiation Oncology,Chang＇an Hospital,Shaanxi Xi＇an 710016,China)
出处
《现代肿瘤医学》
CAS
2018年第23期3823-3826,共4页
Journal of Modern Oncology
关键词
放疗
SBRT
肺肿瘤
radiotherapy
SBRT
lung cancer
作者简介
贺选（1983-），男，陕西西安人，主治医师，主要从事以放疗为主的肿瘤综合治疗与多学科诊疗工作。E—mail：271536684@qq．com;【通讯作者】张学成（1963-），男，陕西澄城人，副主任医师，主要从事以肿瘤放射治疗为主的综合诊疗工作。E—mail：13571987537@139．com
