摘要
白念珠菌是人类最常见的条件性致病真菌之一,主要定植于人体粘膜表面。在白念珠菌与宿主相互作用过程中,分泌型蛋白起着非常重要的作用。针对分泌蛋白功能及其作用机理的研究有助于阐明白念珠菌致病分子机制,并为诊断、预防和治疗真菌感染提供新的理论策略。本文综述了白念珠菌分泌型蛋白在介导病原与宿主相互作用分子机制方面的最新研究进展,概括了分泌蛋白在组织侵入损伤、营养获取、细胞壁维持以及免疫逃避等方面的功能,同时对未来值得重点关注的研究方向进行了探讨。
Candida albicans is one of the most common opportunistic human fungal pathogens and mainly colonizes on the surface of human mucosa. It has been appreciated that secreted proteins of C. albicans play vital roles in mediating the interactions of this fungus with the host. Understanding the functions and action modes of secreted proteins will greatly benefit the study of pathogenesis of C. albicans and provides novel strategies for diagnosis, prevention and treatment of fungal infections. In this review, we describe the latest progresses in studying the secreted proteins in C. albicans and summarize their functions in tissue invasion, nutrient acquisition, cell wall maintenance and immune evasion when the fungus meets with the host. A few major directions that may gain more insights into this area is proposed.
作者
王园园
陈昌斌
WANG Yuan-Yuan;CHEN Chang-Bin(CAS Key Laboratory of Molecular Virology ＆ Immunology,Institut Pasteur of Shanghai,Chinese Academy of Sciences,Shanghai,200031,China;University of Chinese Academy of Sciences,Beijing 100049,China)
出处
《菌物学报》
CAS
CSCD
北大核心
2018年第10期1364-1377,共14页
Mycosystema
基金
国家自然科学基金(31570140)~~
关键词
白念珠菌
分泌型蛋白
病原与宿主互作
致病机制
Candida albicans
secreted protein
host-pathogen interaction
virulence mechanisms
作者简介
Corresponding author:陈昌斌,博士,中国科学院上海巴斯德研究所病原真菌感染与宿主免疫课题组组长,研究员,博士生导师,中科院百人计划获得者。从事人类致病真菌共生和感染的分子机制,毒力基因表达调控机制以及宿主抗真菌的免疫应答机理研究。针对临床重要的传染性疾病防治,包括微生物耐药、器官移植过程的共感染、真菌感染引起的妇科疾病、皮肤感染、脑膜炎和败血症等研发病原诊断新技术及筛选新型抗感染先导药物。已在包括《Cell》《Nature Genetics》《Cell Host&Microbes》《PLoS Pathogens》等国际学术期刊发表论文20余篇。E-mail:cbchen@ips.ac.cn
