摘要
自噬是细胞质大分子或细胞器在溶酶体中降解以维持细胞平衡的过程,在肿瘤的生物学中起着重要作用。自噬相关基因5（autophagy-related gene 5,ATG5）是自噬体形成关键调控者之一,近年来,许多研究报道ATG5在多种肿瘤中的表达不尽相同,对肿瘤的影响也并不一致。文章就ATG5在肿瘤发生发展及治疗和预后中的作用作一综述。
Autophagy is the process of degradation of cytoplasmic macromolecules or organelles in lysosomes to maintain cell balance and plays an important role in tumor biology. Autophagy-related gene 5（ATG5） is one of the key regulators of autophagosome formation. In recent years,many studies have reported that the expression of ATG5 in various tumors is not the same,and its effect on tumors is different. The role of ATG5 in tumor development,treatment and prognosis are reviewed in this article.
作者
张玉梅
冯凡
林方方
许文林
沈慧玲
ZHANG Yu-mei;FENG Fan;LIN Fang-fang;XU Wen-baio;SHEN Hui-ling(Medical College of Jiangsu University,Zhenjiang 212013,china;The Fourth Hospital of Jiangsu University,Zhenjiang 212001,China;People＇s Hospital of Jiangsu University,Zhenjiang 212002,China)
出处
《中国肿瘤》
CAS
CSCD
北大核心
2018年第10期774-778,共5页
China Cancer
基金
国家自然科学基金(81672913)
江苏省自然科学基金(BK20141288)
江苏省高层次卫生人才“六个一工程”科研项目(LGY2017021)
作者简介
通讯作者：沈慧玲。E—mail：shenhuilng0826@163．com
