摘要
目的探究紫杉醇联合顺铂同步治疗非小细胞肺癌的效果。方法随机抽取2017年1月—2018年2月在该院接受非小细胞肺癌治疗的80例患者为研究对象,依据治疗方式差异分为对照组和观察组,对照组接受传统放疗,观察组在上述基础上再接受紫杉醇联合顺铂同步放化疗。比较两组患者的治疗效果和发生不良反应情况。结果观察组患者的好转率为85.0%,明显高于对照组的65.0%,差异有统计学意义(χ~2=16.325,P=0.021);观察组的恶心呕吐、脱发、血红蛋白减少、血小板减少及白细胞减少率显著高于对照组,差异有统计学意义(P<0.05),而两组患者的腹泻率之间差异无统计学意义(χ~2=1.21,P=0.35)。结论顺铂联合紫杉醇同步治疗非小细胞肺癌的效果较佳,因治疗后不良反应较多,应依据患者的实际情况合理选择临床治疗方案。
Objective To study the effect of concurrent therapy paclitaxel combined with cisplatin for nonsmall-cell lung cancer. Methods 80 cases of patients with nonsmall-cell lung cancer admitted and treated in our hospital from January 2017 to February 2018 were selected and divided into two groups according to the different treatment methods,the control group used the traditional radiotherapy, while the observation group were treated with concurrent therapy paclitaxel combined with cisplatin, and the treatment effect and occurrence of adverse reactions of patients were compared between the two groups. Results The improvement rate of patients in the observation group was obviously higher than that in the control group [85.0% vs 65.0%,the different was statistically significant（χ2=16.325,P=0.021）], and the vomiting and nausea, alopecia, hemoglobin reduction, thrombocyte reduction and leukocyte reduction rate in the observation group were obviously higher than those in the control group,the different was statistically significant（P0.05）, and the difference in the diarrhoea rate between the two groups was not statistically significant（χ2=1.21,P=0.35）. Conclusion The effect of concurrent therapy paclitaxel combined with cisplatin for nonsmall-cell lung cancer is better, therefore, the adverse reactions are more, and we should rationally select the clinical treatment plan according to the practical conditions of patients.
作者
李雪芹
LI Xue-qin(Department of Respiration,Xuzhou Tumor Hospital,Xuzhou,Jiangsu Province,221005 China)
出处
《系统医学》
2018年第16期138-140,共3页
Systems Medicine
关键词
非小细胞肺癌
紫杉醇
顺铂
同步放化疗
Nonsmall-cell lung cancer
Paclitaxel
Cisplatin
Concurrent chemoradiotherapy
作者简介
李雪芹（1983-），女，安徽萧县人，本科，主治医师，研究方向：呼吸内科学，肿瘤化疗及靶向治疗。
