摘要
目的:观察不同剂量右美托咪定经滴鼻用药在儿童口腔诊疗中的镇静效果。方法:90例不能配合口腔诊疗操作的患儿随机分为低剂量、中剂量和高剂量3组,各30例,分别根据体重经鼻腔滴入右美托咪定1. 5μg/kg、2. 0μg/kg及2. 5μg/kg进行镇静。观察口腔诊疗中患儿的镇静程度、治疗依从性和用药后的心率、血氧饱和度及不良反应发生情况。结果:3组患儿各时间点心率、血氧饱和度比较差异无统计学意义(P> 0. 05)。在镇静程度、治疗依从性上,中剂量组及高剂量组均高于低剂量组,差异有统计学意义(P <0. 05)。结论:右美托咪定滴鼻作为儿童口腔诊疗中的镇静用药,对生命体征影响小,对自主呼吸没有抑制作用,而患儿的镇静程度、治疗依从性高,其中2. 0μg/kg右美托咪定滴鼻为较适合的用药剂量,更有利于牙科畏惧症儿童的口腔诊疗。
[Objective] To observe the sedative effect of different doses of intranasal dexmedetomidine in children＇s oral diagnosis and treatment. [Method]90 cases of children w ho could not cooperate w ith oral diagnosis and treatment w ere randomly divided into 3 groups： low dose group,middle dose group and high dose group,respectively,according to the w eight of the nasal drops into the dexmedetomidine 1. 5μg/kg,2. 0μg/kg and 2. 5μg/kg for sedation. The degree of sedation,treatment compliance and heart rate,oxygen saturation and the incidence of adverse reactions during oral treatment w ere observed. [Result] There w ere no statistically significant differences in heart rate and oxygen saturation betw een the three groups using repeated measures analysis of variance（ P〈0. 05）. How ever,in terms of sedation and treatment compliance,the middle dose group and the high dose group w ere higher than the low dose group（ P〈0. 05）.[Conclusion]Dexmedetomidine is a sedative drug used in children＇s oral diagnosis and treatment. It has little effect on vital signs and has no inhibitory effect on spontaneous breathing. And,the degree of sedation and treatment compliance w as high in children,of w hich 2. 0μg/kg dextral Tommyidine is a more suitable dosage. It is more conducive to dental care for children w ith dental fear.
作者
徐丹兵
刘丹萍
戴杰
XU Danbing;LIU Danping;DAI Jie(Enze Hospital of Taizhou,Enze Medieal Center（Group）,Zhejiang 318050,China)
出处
《浙江医学教育》
2018年第5期49-51,共3页
Zhejiang Medical Education
作者简介
徐丹兵（1983-），男，浙江台州人，本科，主治医师。研究方向：临床麻醉学
