摘要
目的研究硝酸甘油对经内镜逆行胰胆管造影术(Encoscopic Retrograde Cholangio Pancreato-graphy,ERCP)后急性胰腺炎的预防作用。方法选择2015年12月~2017年12月本院收治的110例ERCP手术患者作为研究对象,以随机数字表法分为试验组和对照组,每组55例。对照组术后采纳常规治疗,试验组术后采纳硝酸甘油治疗。比较两组患者血清淀粉酶水平、C反应蛋白(CRP)水平以及并发症发生情况。结果术前两组血清淀粉酶水平比较差异无统计学意义;术后3 h、6 h、12 h试验组血清淀粉酶水平显著低于对照组,差异有统计学意义(P<0.05);术前两组CRP水平比较差异无统计学意义;术后3 h、6 h、12 h试验组的CRP水平显著低于对照组,差异有统计学意义(P<0.05)。试验组并发症发生率(1.82%)显著低于对照组的(23.64%),两组比较差异有统计学意义(c2=13.557 8,P=0.000 2<0.05)。结论硝酸甘油用于ERCP术后,可有效预防急性胰腺炎的发生,疗效确切,值得借鉴。
Objective To study the preventive effect of nitroglycerin on acute pancreatitis after endoscopic retrograde cholangiopancreatography （ERCP）. Methods A total of 110 patients with ERCP who underwent surgery from December 2015 to December 2017 were enrolled in the study.They were randomly divided into the experimental group and the control group, with 55 patients in each group. The control group received routinetreatment after surgery, and the test group received nitroglycerin after surgery. Serum amylase levels, C-reactive protein （CRP） levels, and complications were compared between the two groups. Results There was no significant difference in serum amylase levels between the two groups before operation. The serum amylase levels in the experimental group were significantly lower than those in the control group at 3 h, 6 h and 12 h after operation （P〈0.05）. There was no significant difference in CRP levels between the two groups before operation. The CRP levels in the experimental group were significantly lower than those in the control group at 3 h, 6 h and 12 h after operation （P〈0.05）. The incidence of complications in the experimental group （1.82%） was significantly lower than that in the control group （23.64%）, and the difference was statistically significant （χ2=13.557 8,P=0.000 2〈0.05）. Conclusion Nitroglycerin can effectively prevent the occurrence of acute pancreatitis after ERCP, and its curative effect is definite.
作者
郑杨
魏松之
周宇昕
Zheng Yang;Wei Songzhi;Zhou Yuxin(The Fourth Affiliated Hospital of Nanchang University,Nanchang,Jiangxi,330000,China)
出处
《当代医学》
2018年第26期1-3,共3页
Contemporary Medicine
基金
江西省卫生计生委科技计划(20175330)
关键词
硝酸甘油
经内镜逆行胰胆管造影
急性胰腺炎
预防作用
Nitroglycerin
Endoscopic retrograde cholangiopancreatography
Acute pancreatitis
Prevention
