摘要
目的探讨阿司匹林联合硫酸镁治疗妊娠期高血压疾病(HDCP)的临床疗效,为临床治疗提供参考依据。方法选择77例患有HDCP且于2015年4月-2017年8月重庆医科大学附属第一医院产科确诊患者为研究对象,依据两种用药方法分组:观察组40例以阿司匹林联合硫酸镁治疗,对照组37例以硫酸镁治疗。对其疗效、血压水平、不良反应及妊娠结局详细记录并进行对比。结果观察组有效率为95.00%(38/40),高于对照组的72.97%(27/37),差异有统计学意义(P<0.05);观察组不良反应发生率为7.50%,低于对照组的24.32%,差异有统计学意义(P<0.05);观察组用药后DBP(舒张压)为(79.28±3.33)mm Hg,SBP(收缩压)为(109.27±2.77)mm Hg,低于对照组的DBP(96.22±3.60)mm Hg与SBP(133.26±3.31)mm Hg,差异有统计学意义(均P<0.05);观察组2例(5.00%)早产、2例(5.00%)宫内窘迫、1例(2.50%)新生儿窒息,低于对照组的早产8例(21.62%)、宫内窘迫9例(24.32%)及新生儿窒息7例(18.92%),差异有统计学意义(均P<0.05)。结论产科给予HDCP患者治疗时,选择阿司匹林联合硫酸镁治疗疗效好、不良反应及不良妊娠结局发生率较低,具有可靠性。
Objective To explore the clinical effect of aspirin combined with magnesium sulfate in treatment of hypertensive disorder complicating pregnancy（ HDCP）,provide a reference basis for clinical treatment. Methods From April 2015 to August 2017,77 patients diagnosed as HDCP definitely in the First Affiliated Hospital of Chongqing Medical University were selected and divided into two groups according to treatment method： 40 patients in observation group were treated by aspirin combined with magnesium sulfate,and 37 patients in control group were treated by magnesium sulfate. The curative effects,blood pressures,adverse reactions,and pregnancy outcomes in the two groups were recorded detailedly and compared. Results The effective rate in observation group was 95. 00%（ 38/40）,which was statistically significantly higher than that in control group（ 72. 97%,27/37）（ P〈0. 05）. The incidence rate of adverse reactions in observation group was 7. 50%,which was statistically significantly lower than that in control group（ 24. 32%）（ P〈0. 05）. Diastolic blood pressure（ DBP） and systolic blood pressure（ SBP） after medication in observation group were（ 79. 28±3. 33） mmHg and（ 109. 27±2. 77） mmHg,respectively,which were statistically significantly lower than those in control group [（ 96. 22 ±3. 60） mmHg and（ 133. 26 ±3. 31） mmHg]（ P〈0. 05）. The incidence rates of premature delivery,fetal intrauterine distress,and neonatal asphyxia in observation group were 5. 00%（ 2 patients）,5. 00%（ 2 patients）,and 2. 50%（ 1 patient）,which were statistically significantly lower than those in control group[21. 62%（ 8 patients）,24. 32%（ 9 patients）,18. 92%（ 7 patients） ]（ P〈0. 05）. Conclusion Aspirin combined with magnesium sulfate in treatment of HDCP has the advantages of good curative effect,low incidence rates of adverse reactions and adverse pregnancy outcomes,which is reliable.
作者
秦可心
QIN Ke-Xin(The First Affiliated Hospital of Chongqing Medical University,Chongqing,400016,China)
出处
《中国妇幼保健》
CAS
2018年第17期3902-3905,共4页
Maternal and Child Health Care of China
关键词
妊娠期高血压疾病
阿司匹林
硫酸镁
疗效
Hypertensive disorder complicating pregnancy
Aspirin
Magnesium sulfate
Curative effect
