摘要
目的分析血清C反应蛋白(CRP)、降钙素原(PCT)在慢性阻塞性肺疾病急性加重期(AECOPD)患者中的临床意义。方法选取80例AECOPD患者为观察组,另选取健康体检者75例为对照组,将观察组患者按是否细菌感染分为细菌感染组和非感染组,按是否死亡分为死亡组和存活组,测定并比较各组患者的CRP值和PCT值,分析CPR与PCT对AECOPD患者的诊断价值。结果观察组患者的CRP、PCT值均高于对照组,细菌感染组患者的CRP值、PCT值均高于非感染组,死亡组患者的CRP值、PCT值均高于存活组,差异均有统计学意义(P<0.05)。血清PCT对AECOPD患者诊断的最佳临界点为1.52μg/L,正确指数为51.75%,ROC曲线下面积为0.723;血清CRP对AECOPD诊断的最佳临界点为20.75 mg/L,正确指数为44.73%,ROC曲线下面积为0.643。结论 PCT和CRP对AECOPD患者的诊断、病情判断及短期预后具有重要意义。
Objective To analyze clinical significance of serum procalcitonin（ PCT） and Creactive protein（ CRP） detection in patients with acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）. Methods A total of 80 patients diagnosed with acute exacerbation of chronic obstructive pulmonary disease were as observation group,and another 75 healthy persons with physical examination were as control group,the patients in the observation group were divided into bacterial infection group and non infection group according to bacterial infection condition,and death group and survival group according to whether death or not,and the CRP and PCT values of each group were measured,then the CRP and PCT values between the observation group and the control group,the bacterial infection group and the non infection group,the death group and the survival group were compared,the diagnostic value of CPR and PCT in patients with AECOPD was analyzed. Results The CRP and PCT values in the observation group were higher than the control group,the bacterial infection group was higher than the non infection group,and the death group was higher than survival group（ P〈0. 05）. The best critical value for the diagnosis of AECOPD by serum PCT was1. 52 μg/L,the correct index was 51. 75%,the area under the ROC curve was 0. 723,and the best critical value of serum CRP was 20. 75 mg/L,the correct index is 44. 73%,and the area under the ROC curve was 0. 643. Conclusion The detection of PCTand CRP is of great significance for diagnosis,disease condition judgment and evaluation short-term prognosis of patients with AECOPD.
作者
史彩雯
施宇佳
陈意
殷小伟
毛正道
SHI Caiwen;SHI Yujia;CHEN Yi;YIN Xiaowei;MAO Zhengdao(Department of Respiratory,Yanghu Division of Changzhou Second People＇s Hospital Affiliated to Nanjing Medical University,Changzhoo,Jiangsp,213164)
出处
《实用临床医药杂志》
CAS
2018年第17期26-28,共3页
Journal of Clinical Medicine in Practice
关键词
慢性阻塞性肺疾病
C反应蛋白
降钙素原
最佳临界值
chronic obstructive pulmonary disease
C-reactive protein
procalcitonin
best crtical value
作者简介
通信作者：毛正道
