摘要
目的通过收集唑来膦酸注射液在临床上常见的不良反应,并对不良反应的特点和规律进行分析,提出预防不良反应发生的有效措施,保证患者用药安全。方法对2011年1月1日~2016年9月30日淄博市药品不良反应中心收集到的94例唑来膦酸注射液不良反应,按照人群年龄与性别、累计系统-器官、发生时间、新的或严重的不良反应等方面进行分析。结果 94例不良反应女性所占构成比明显高于男性,46岁以上患者不良反应发生率最高;临床累及器官或系统主要为包括全身性、神经系统、消化系统、皮肤及其附件系统、泌尿系统、呼吸系统损害等;不良反应发生时间多为在用药后24 h内,属速发型不良反应。结论生产企业应加强女性患者和中老年患者用药方面的研究工作,临床上应密切监护,规范用药,保证患者用药安全。
Objective To put forward the effective measures for preventing the occurrence of adverse reactions and ensure the safety of the patients by collecting the common adverse reactions of Zoledronic Acid Injection in clinic,and analyzing the characteristics and laws of adverse reactions.Methods According to the age and sex of the population,the cumulative system-organ,the time of occurrence,the new or the adverse effect of zoledronic acid injection on 94 cases of zoledronic acid injection adverse reactions collected by Zibo Center for ADR Monitoring from January 1 st 2011 to September 30 th2016.Results The incidence of adverse events proportion of female was more higher than male,The incidence of adverse reactions was highest in patients over 46 years of age,involving mainly systemic organ or system damage,including nervous system,digestive system,skin and the appendages,urinary system and respiratory system. Adverse reactions occurred less than 24 hours after treatment within the fast hair type of adverse reactions. Conclusion Pharmaceutical manufacturers should strengthen the study on the use of drugs in women patients and middle-aged and elderly patients.It should be closely monitored and regulate medication in clinical to ensure the medication safety of patients.
作者
张歆
周文琦
ZHANG Xin;ZHOU Wenqi(ZiBo Center for ADR Monitoring,Zibo 255020,China)
出处
《药学研究》
CAS
2018年第8期493-495,共3页
Journal of Pharmaceutical Research
关键词
唑来膦酸注射液
不良反应
含氮双膦酸盐类药物
Zoledronic Acid Injection
Adverse drug reaction
Nitrogen-containing bisphosphonates drug
作者简介
张歆，男，主管药师，研究方向：药品不良反应监测，E-mail：2804075527@qq．com
