摘要
目的探讨血清CA125、CA199检测、联合妇科B超及MRI检查在卵巢肿瘤早期诊断中的价值。方法回顾性分析83例卵巢癌及107例卵巢良性肿瘤患者的血清学CA125、CA199及妇科B超和MRI检查临床病理资料,分析各种诊断方法的敏感度、特异度等。对比分析不同诊断方法,判定诊断方法的准确度。结果卵巢癌组血清CA125、CA199浓度水平显著高于卵巢良性肿瘤组,且差异均有统计学意义(P<0.05),其中CA125浓度水平增高较CA199更为明显。联合检测时卵巢癌的诊断灵敏度高于其他组,漏诊率显著低于其他组。而特异度高于单用肿瘤标志物及妇科B超组、低于单用MRI组。联合检测组灵敏度及特异度均较其他组有所提高,诊断指数及准确诊断指数均高于其他各组。结论血清CA125、CA199联合B超及MRI检查,在一定程度上可提高卵巢癌早期的诊断率,值得在临床上进一步推广应用。
Objective To investigate the value of serum CA125,CA199,combined gynecological B ultrasound and gynecological MRI in the early diagnosis of ovarian cancer. Methods The clinical and pathological data of 83 patients with ovarian cancer and 107 patients with benign ovarian tumors were retrospectively analyzed. The sensitivity and specificity of different diagnostic methods were analyzed. Different diagnostic methods were comparatively analyzed in order to determine the accuracy of diagnostic methods. Results The serum levels of CA125 and CA199 in ovarian cancer group were significantly higher than those in benign ovarian tumor group（P 〈0. 05）,and the CA125 concentration was higher than CA199. The diagnostic sensitivity of combined methods in ovarian cancer was higher than that of other groups,and the rate of missed diagnosis of combined method in ovarian cancer was significantly lower than other groups. The specificity of combined method was higher than single tumor markers and gynecological B ultrasound group,lower than single MRI group. The sensitivity and specificity of the combined method group were higher than other groups,and the diagnostic index and the accurate diagnostic index were higher than the other groups. Conclusion The combination of serum CA125 and CA199 with B ultrasound and MRI can improve the early diagnosis rate of ovarian cancer to a certain extent,which is worth to be further popularized in clinic.
作者
马财
田素升
缑文斌
陈文静
MA Cai;TIAN Su Sheng;GOU Wen Bin;CHEN Wen Jing(The Sixth Division Hospital of the Xinfiang Production and Construction Corps, Wujiaqu 831300, China)
出处
《中国妇幼卫生杂志》
2018年第4期82-85,共4页
Chinese Journal of Women and Children Health
基金
兵团卫生科技项目(201717)-磁共振功能成像在卵巢肿瘤中的临床应用研究
作者简介
通信作者：陈文静，Email：wen-jing333@163．com
