摘要
目的观察前列地尔对冠心病合并糖尿病经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)患者对比剂肾病的预防作用。方法回顾性分析本院2015年1月~2016年12月接受PCI治疗的84例冠心病合并糖尿病患者的临床资料,根据治疗方式不同分为对照组(40例)及观察组(44例)。对照组单纯实施PCI治疗,观察组在实施PCI治疗前1d加用前列地尔。观察并比较两组术后肾功能指标水平及对比剂肾病发生率。结果术后48h,观察组肾功能指标水平明显优于对照组,差异有统计学意义(P<0.05);观察组术后对比剂肾病发生率明显低于对照组,差异有统计学意义(P<0.05)。结论冠心病合并糖尿病患者PCI治疗前为患者使用前列地尔,有效改善患者术后肾功能,降低术后对比剂肾病发生风险,预防效果显著。
Objective To observe the preventive effect of alprostadil on contrast nephropathy in patients with coronary heart disease and diabetes mellitus undergoing percutaneous coronary intervention（PCI）. Methods The clinical data of 84 patients with coronary heart disease and diabetes mellitus treated by PCI in our hospital from January 2015 to December 2016 were retrospectively analyzed. The patients were divided into control group（40 cases） and experimental group（44 cases） according to different treatment methods. The patients in the control group received PCI treatment, and the patients in the experimental group received alprostadil in the implementation of PCI 1 days before treatment. The renal function indexes and the incidence of contrast nephropathy were observed and compared between the two groups. Results The level of renal function in the experimental group was significantly better than that in the control group after 48 h of operation, and the difference was statistically significant（P 0.05）. The incidence of contrast nephropathy in the experimental group was significantly lower than that in the control group, the difference was statistically significant（P 0.05）. Conclusion Patients with coronary heart disease and diabetes mellitus were treated with alprostadil before PCI, which could effectively improve the postoperative renal function and reduce the risk of postoperative contrast nephropathy, and the preventive effect was remarkable.
作者
张新芝
田玉生
ZHANG Xin-zhi;TIAN Yu-sheng(Internal Medicine Department,Suixian Hospital of Traditional Chinaese Medicine,Shangqiu,Henan,476900,China)
出处
《临床研究》
2018年第7期53-54,共2页
Clinical Research
关键词
冠心病
糖尿病
PCI治疗
前列地尔
对比剂肾病
coronary heart disease
diabetes mellitus
PCI treatment
alprostadil
contrast nephropathy
作者简介
张新芝（1977-）,女,汉族,河南商丘睢县人,主治医师,本科.研究方向：内分泌,糖尿病.
