摘要
目的采用Meta分析的方法评价体能锻炼对成人肾移植受者术后生理功能的影响，为临床实践提供理论依据。方法计算机检索Cochrane图书馆、PubMed、Embase、Webof Science、万方数据、中国知网等数据库。文献检索起止时间均从建库至2017年10月，收集体能锻炼干预肾移植受者术后的随机对照试验（RCT），提取资料后使用RevMan5．3软件进行数据分析。结果共纳入10篇文献，10项RCT研究，包括557例对象。Meta分析结果显示，与常规药物治疗组相比，体能锻炼组（体能锻炼＋常规治疗）肾移植受者术后峰值摄氧量（PeakVO2）明显升高，差异有统计学意义（MD=2．40，95％CI 0．15～4．64，P=0．04）；两组肾移植受者血脂、血压、血红蛋白及血肌酐变化值差异均无统计学意义（均P〉0．05）。结论体能锻炼可提高肾移植受者术后早期心肺耐力，但对血压、血脂、血红蛋白及血肌酐均无明显影响。
Objective To assess the impact of physical training on physiological function of adult renal transplant recipients by metaanalysis and to provide theoretical guidance for clinical practice. Methods Randomized controlled trials of physical training for the treatment of renal transplant recipients until October 2017 were searched in the database of Cochrane library, PubMed, Embase, Web of Science, Wanfang Data and CNKI. Data extracted from the literatures were analyzed with RevMan software （version 5.3）. Results A total of 10 studies in 10 manuscripts met the inclusion criteria, and 557 cases were included. Meta-analysis results were as follows. Compared with the control group （routine drug therapy）, the level of peak exercise oxygen uptake （peak V02） was significantly increased in physical training group （routine drug therapy and physical training） （MD= 2.40, 95% CI 0.15-4.64, P-0.04）. However, there was no statistically significant difference in the change of blood lipid, blood pressure, hemoglobin and serum creatinine between the two groups （all P 〉 0.05）. Conclusions Physical training can improve cardio respiratory fitness of renal transplant recipients in the early stage, but it has no obvious effect on blood pressure, blood lipid, hemoglobin and blood ereatinine.
作者
熊晓燕
白寿军
王亚琨
姬婷婷
杜红秀
李肖瑛
高聪普
刘娟
朱迎春
查芳芳
Xiong Xiaoyan;Bai Shoujun;Wang Yakun;Ji Tingting;Du Hongxiu;Li Xiaoying;Gao Congpu;Liu Juan;Zhu Yingchun;Zha Fangfang(Department of Nephrology,Zhongshan Hospital Qingpu Branch,Fudan University,Shanghai 201700,China)
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2018年第6期424-431,共8页
Chinese Journal of Nephrology
基金
上海市自然科学基金（13ZR1407200）
上海市卫计委基金（20124231）
关键词
META分析
运动
肾移植
随机对照试验
Meta-analysis
Exercise
Kidney transplantation
Randomized controlled trial
作者简介
通信作者：白寿军，Email：baishoujun@126．com
