摘要
目的利用中国东北地区城市儿童肺功能调查数据验证GLI2012亚洲地区肺功能预测方程的适用性,为制定更合适亚洲人群的肺功能评价体系和指标提供参考。方法 2016年7—12月,在中国东北地区中心城市H市、C市、S市,采用典型抽样和单纯随机抽样相结合的方法,选取健康的8~10岁小学生841名,进行问卷调查和肺功能检测。结果用力肺活量(FVC)预测值高于实测值,1 s用力呼气量(FEV1)、1 s率(FEV1/FVC)预测值低于实测值,差异均有统计学意义(P值均<0.05)。东北亚方程预测值和实测值在男女生中的差异度FVC为28%和32%,FEV1为20%和27%;校正系数FVC为0.78和0.76,FEV1为0.84和0.79。东南亚方程预测值和实测值在男女生中的差异度FVC为17%和16%,FEV1为13%和14%;校正系数FVC为0.84和0.86,FEV1为0.89和0.88。医学参考值下限预测值中,东北亚方程和东南亚方程中男女生FVC,FEV1单一指标假阳性率远高于正常范围,FEV1/FVC略高于正常范围。结论 GLI2012东北亚、东南亚方程经东北地区健康儿童肺功能数据验证,预测值均高于实测值,需要利用校正系数进行校正。
Objective To evaluate the applicability of the Global Lung Function Initiative reference values（ GLI2012） among children aged 8-10 years old in Northeastern China. Methods Between July and December in 2016, 841 healthy pupils,aged from 8 to 10 years old, were chosen from three central cities in Heilongjiang, Jilin and Liaoning provinces, Northeastern of China, by using random sampling. Reference values and lower limits of normality（ LLN） of forced vital capacity（ FVC）, forced expiratory volume in one second（ FEV1） and FEV1/FVC ratio were calculated, using age-and height-specific GLI2012 North and South East Asian equations. The difference between predicted and measured values was compared and the correction coefficients were calculated. Results The predicted value of FVC, FEV1 and FEV1/FVC was higher than the actual value. The magnitude of difference between the predicted and measured values of the Northeast Asian equation for FVC and FEV1 was 28% and 32%, 20%and 27% in boys and girls, respectively. The correction coefficients were 0.78 and 0.76 for FVC, 0.84 and 0.79 for FEV. The magnitude of difference between the predicted and measured values in Southeast Asian equation was 17% and 16% for FVC, 13% and14% for FEV1, respectively. The correction coefficients were 0.84 and 0.86 for FVC, 0.89 and 0.88 for FEV1. The false positive rate of FVC and FEV1 in the Northeast Asia equation and the Southeast Asian equation was significantly higher than that in the normal range, and the FEV1/FVC was slightly higher than the normal range. Conclusion GLI2012 Northeast Asian and Southeast Asian equations were validated by the lung function data of healthy children in Northeastern China. The predicted values were higher than the measured values, and should be corrected by the correction coefficients.
作者
李亚伟
李成橙
陈晨
刘静怡
孟聪申
何英华
崔仲明
刘晓秋
吴静
王俊龙
郑晶
潘阳
孙丽
刘晓波
韩京秀
LI Yawei;LI Chengcheng;CHEN Chen;LIU Jingyi;MENG Congshen;HE Yinghua;CUI Zhongming;LIU Xiaoqiu;WU Jing;WANG Junlong;ZHENG Jing;PAN Yang;SUN Li;LIU Xiaobo;HAN Jingxiu(Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing（100021）, China)
出处
《中国学校卫生》
CAS
北大核心
2018年第6期818-821,共4页
Chinese Journal of School Health
基金
公益性行业科研专项(201402022
201502003)
关键词
预测
肺
儿童
亚洲
呼吸功能试验
Forecasting
Lung
Child
Asia
Respiratory function tests
作者简介
李亚伟（1982-），男，河北廊坊人，硕士，助理研究员，主要研究方向为环境流行病学。;【通讯作者】韩京秀，E-mail：hanjxcdc@139．com。
