摘要
主要探讨采用相转移催化法由苯甲醛和正庚醛经羟醛缩合合成茉莉醛的合成工艺。通过单因素试验法和正交试验法确定了合成茉莉醛的最佳工艺条件,当以4.567 g(0.04 mol)正庚醛为基准,苯甲醛与正庚醛的物质的量比为1.2:1,水25 mL,乙醇10 mL,氢氧化钾1.000 g(0.02 mol),PEG-400的用量为正庚醛的3%,60℃下反应4 h,茉莉醛粗产率达到84.3%,其结构经核磁共振氢谱和碳谱验证。
Jasminaldehyde is a very valuable synthetic aroma chemical. Its synthetic process by aldol condensation of benzaldehyde and n-heptylaldehyde under phase transfer catalysis was mainly discussed in this paper. The optimal reaction conditions determined by both the single factor experiment and the orthogonal experiment were as follows： when 4.567 g（0.04 mol） heptylaldehyde was used, the reactant molar ratio of benzaldehyde to heptylaldehyde was 1.2 to 1, the amount of water was 25 mL, ethanol was 10 mL, KOH was 1.000 g（0.02 mol）, PEG-400 was 3% mole ratio of n-heptylaldehyde, reaction temperature was 60 ℃, reaction time was 4 hours, the yield of jasminaldehyde reached as high as 84.3%.
作者
陈敏琼
刘继鸿
蔡泽威
李梓童
张红
CHEN Min - qiong;LIU Ji - hong;CAI Ze - wei;LI Zhi - tong;ZHANG Hong(School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528458, Guangdong, China;Guangdong Cosmetics Engineering ＆ Technology Research Center, Guangzhou 510006, Guangdong, China)
出处
《香料香精化妆品》
CAS
2018年第3期17-23,共7页
Flavour Fragrance Cosmetics
关键词
茉莉醛
正庚醛
相转移催化法
正交试验法
jasminaldehyde
n- heptylaldehyde
phase transfer catalysis
orthogonal experiment
作者简介
陈敏琼（1994-），女，实验师，主要从事香料等精细化工产品的合成研究。;通信作者：张红（1970-），女，博士，副教授，主要从事精细化学品的合成和性能研究。联系电话：13610060760 E-mail：phdzhangh@163．com
