摘要
目的探讨人类乳头瘤病毒(HPV)亚型与子宫颈癌前病变及癌变的关系。方法选取2016年2月至2018年2月间山东省立第三医院收治的意义不明确的非典型鳞状细胞(ASC-US)及以上异常、HPV检测任一高危型亚型阳性、宫颈上皮内瘤变Ⅱ(CINⅡ)、宫颈上皮内瘤变Ⅲ(CINⅢ)和宫颈浸润癌的379例患者进行回顾性分析。结果 HPV感染患者337例(88.9%),其中HPV亚型单型别271例,多重感染66例,主要为二重感染。每个被HPV多重感染的患者均有1个及以上高危型别HPV存在,其中主要为HPV16,阳性率为30.8%,其次为HPV58和HPV52,阳性率分别为13.0%和12.0%。CINⅢ患者的HPV感染率显著高于CINⅡ和宫颈浸润癌患者,差异均有统计学意义(均P<0.05),HPV16与子宫颈癌前病变及癌变严重程度密切相关。CINⅡ、CINⅢ和宫颈浸润癌患者的HPV16感染率分别为24.2%(8/33)、34.1%(29/85)和38.1%(8/21)。结论 HPV亚型与子宫颈癌前病变及癌变密切相关,值得临床充分重视。
Objective To study the relationships between human papilloma virus（ HPV） subtypes and cervical precancerous lesion and canceration. Methods The clinical data of 379 patients treated at Shandong Provincial Third Hospital for atypical squamous cells of undetermined signification（ ASC-US） and above abnormality,with high risk,subtype or positive HPV,cervical intraepithelial neoplasia II（ CIN II）,CIN III or invasive cervical cancer from February 2016 to February 2018 were retrospectively analyzed.Results Among 337 patients infected with HPV（ 88. 9%）,271 were subtypes of HPV as single type and67 had multiple infections,which were mainly double infection. Every patient with multiple infections of HPV had one or more than one high risk type. Among them,HPV16 made up 30. 8% of the positive rate,which was followed by HPV58 and HPV52 with the positive rate of 13. 0% and 12. 0% respectively. The HPV infection rate was significantly higher in patients with invasive cervical cancer than in patients with CIN II and CIN III（ all P〈 0. 05）. HPV16 was closely related to the severity of precancerous lesions. The HPV16 infection rates of CIN II,CIN III and cervical invasive cancer were 24. 2%（ 8/13）,34. 1%（ 29/85） and 38. 1%（ 8/21） respectively. Conclusion HPV subtypes are closely related to cervical precancerous lesions and canceration. Thus,it is worthy of full attention.
作者
戴永刚
张乃馨
穆家康
DAI Yong-gang;ZHANG Nai-xin;MU Jia-kang(Department of Clinical Laboratory, Shandong Provincial Third Hospital, Jinan 250031, China;Binzhou Medical University School of Clinical Medicine, Binzhou 264033, China;Qilu Polytechnic University School of Chemistry and Pharmaceutical Engineering,Jinan 250353, China)
出处
《中国肿瘤临床与康复》
2018年第6期657-659,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
HPV亚型
子宫颈癌前病变
癌变
HPV subtypes
Cervical precancerous lesions
Canceration
作者简介
戴永刚，男，主管技师，主要从事出凝血检验专业。
