摘要
巨噬细胞通过细胞表型转换与内环境的变化相适应。M1型巨噬细胞具有促炎作用,而M2型巨噬细胞具有抗炎和促纤维化作用。进展的易损动脉粥样硬化斑块内以M1型巨噬细胞为主。糖酵解是M1型巨噬细胞主要的供能途径,伴随细胞内大量活性氧的生成和炎性细胞因子的分泌。而稳定动脉粥样硬化斑块内以M2型巨噬细胞为主,M2型巨噬细胞以氧化磷酸化为主要供能途径,通过抑制巨噬细胞糖酵解,促进巨噬细胞氧化磷酸化,能够减轻动脉粥样硬化病变。本文综述了与巨噬细胞表型转换相适应的细胞能量代谢变化及其对动脉粥样硬化斑块进展和斑块稳定性的影响及其作用机制。
Macrophage phenotype conversion occurs in the tissue in concomitance with the stimuli of various factors in the internal environment. M1 macrophages are considered to pro-inflammatory while M2 macrophages support the effects on anti-inflammatory and pro-fibrotic factors. M1 macrophages, which are supported by glycolysis for ATP production accompanied by reactive oxygen species generation and inflammatory cytokines secretion, are the predominant macrophage population in rupture-prone zones and abundant in unstable plaques, whereas M2 macrophages, being higher in stable plaques, have an increased the capacity of oxidative phosphorylation which is essential to relieve the atherosclerotic lesions. This review summarized the mechanisms of cellular energy metabolism that is suitable for supporting the macrophage phenotype which contributes to atherosclerotic plaque progression or stability.
作者
巢汝
黄靓
屈顺林
张弛
CHAO Ru;HUANG Liang;QU Shunlin;ZHANG Chi(Key Lab for Arteriosclerology of Hu＇nan Province, Institute of Cardiovascular Disease, University of South China, Hengyang 421001, China)
出处
《生命的化学》
CAS
CSCD
2018年第3期478-482,共5页
Chemistry of Life
基金
国家自然科学基金项目(81100106
81100212
81670424)
南华大学博士科研启动基金(2012XQD37)
作者简介
通信作者:张弛,E-mail:zhangchi9966@163.com
