摘要
目的探讨氟康唑两种给药方法治疗难治性外阴阴道假丝酵母菌病(VVC)的疗效对比。方法选取2014年1月至2017年1月本院收治的难治性VVC患者200例,依据随机数字表法分为单次组和巩固组,每组100例,单次组给予150 mg氟康唑单次口服治疗,巩固组给予150 mg氟康唑巩固口服治疗(1次/天,连续3 d,下次月经干净后再给药1次),比较2组患者临床症状缓解时间、治疗疗效、不良反应、复发情况。结果单次组和巩固组阴道瘙痒感、腰腹部疼痛感、阴道分泌物、黏膜充血性水肿缓解时间和治疗有效率、不良反应发生率基本相同,差异无统计学意义(P>0.05);随访12个月期间,巩固组复发率明显低于单次组,差异有统计学意义(P<0.05)。结论与单次给药比较,氟康唑巩固给药治疗难治性VVC也具有良好的疗效和安全性,可有效减少患者的复发,值得临床推广应用。
Objective To discuss the efficacy comparison of two administration methods of fluconazole in the treatment of intractable vulvovaginal candidiasis（ VVC）. Methods 200 patients with intractable VVC were selected in our hospital from January 2014 to January2017; according to the random number table,all patients were divided into single-dose group and consolidation group,each with 100 cases; the single-dose group was orally administered a single dose of 150 mg fluconazole,while the consolidation group was orally administered 150 mg oral fluconazole（ 1 time/d,continuous treatment for 3 d,and administering it 1 time after next menstruation）; the clinical symptom remission time,curative effect,adverse reaction and recurrence were compared in two groups. Results The vaginal itching,abdomen pain,vaginal secretion,mucosal hyperemia,edema remission time and the treatment efficiency rate,adverse reaction rate of single group and consolidation group were basically the same; and the difference was not statistically significant（ P〉0. 05）. During the 12-month follow-up,the recurrence rate of consolidated group was significantly lower than that of single-dose group,the difference was statistically significant（ P〈0. 05）. Conclusion Compared with the single dose,the fluconazole consolidation therapy also has the good therapeutic efficacy and safety in the treatment of intractable VVC,and it can effectively reduce the recurrence of patients,so it is worth further clinical promotion.
作者
王玲
刘荣
王首玉
陈燕
李晖
WANG Ling;LIU Rong;WANG Shou-yu;CHEN Yan;LI Hui(Department of Obstetrics and Gynecology,Jingzhou Central Hospital,Jingzhou Hubei 434020,Chin)
出处
《局解手术学杂志》
2018年第5期364-367,共4页
Journal of Regional Anatomy and Operative Surgery
关键词
氟康唑
给药方法
难治性
外阴阴道假丝酵母菌病
疗效
fluconazole
administration methods
intractability
vulvovaginal candidiasis
efficacy
作者简介
通信作者,刘荣,E-mail：liurongjy@163.com
