摘要
目的:优化五黄液中冰片的最佳溶解工艺。方法:采用GC法,以萘为内标,冰片含量为评价指标,采用-响应面优化法(Central Composite Design-Response Surface Method CCD-RSM)优化五黄液中冰片最佳溶解工艺参数。结果:最佳溶解工艺参数为乙醇∶吐温∶冰片=9∶3∶1,冰片的平均含量为68.2%。结论:CCD-RSM设计科学、预测性好,所得的冰片溶解工艺简便稳定,合理可行。
Objective: To optimize the preparation of borneol in Wuhuangye. Methods: Using Gas chromatography, taking the contents of naphthalene as internal standard and the contents of borneol as indexes, optimizing the preparation of borneol in Wuhuangye by using Central Composite Design-Response Surface Method (CCD-RSM) . Results: The best preparation technology were as follows: alcohol: twain: borneol =9: 3: 1, the contents of borneol was 68. 2%. Conclusion: CCD-RSM is scientific and predictability, this technology is simple, stable, reasonable and feasible.
作者
廖芳
田吉
陈斯玮
谭天林
王欢
马书军
张丹
Liao Fang;Tian Ji;Chen Siwei;Tan Tianlin;Wang Huan;Ma Shujun;Zhang Dan(Traditional Chinese Medicine Hospital of Xindu district, Chengdu, 610500, China;Research Center for Drug Discovery, Southwest Medical University, Luzhou, 646000, China;Pharmacy Department, Southwest Medical University, Luzhou, 646000, China)
出处
《成都中医药大学学报》
2018年第2期15-17,126,共4页
Journal of Chengdu University of Traditional Chinese Medicine
基金
全国中药特色技术传承人才培训项目(J20164811007)
成都市新都区科技局项目
作者简介
第一作者:廖芳,女,1975年生;硕士,副主任中药师;E—mail:67077496@qq.com。;通信作者:张丹,女,1975年生;博士,副教授;E—mail:393335427@qq.com。